Tert-butyl 3-(1-hydroxypropyl)benzoate | 945222-47-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl 3-(1-hydroxypropyl)benzoate
• 英文别名: tert-butyl 3-(1-hydroxypropyl)benzoate
• CAS: 945222-47-9
• 化学式: C₁₄H₂₀O₃
• 分子量: 236.311
• InChiKey: SKHHEQGGYBETMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl 3-(1-hydroxypropyl)benzoate 在 一水合肼 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 19.0h， 生成 Tert-butyl 3-(1-aminopropyl)benzoate
  参考文献：
  名称：

  Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors

  摘要：

  A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones was designed, synthesized, and evaluated as human chymase inhibitors. From this series, we identified several compounds which were effective, via oral administration, in a mouse model of chronic dermatitis. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.085
• 作为产物：
  描述：

  3-羧基苯甲醛 在 copper(l) iodide 作用下， 以 乙醚 、 二氯甲烷 、 叔丁醇 为溶剂， 反应 16.5h， 生成 Tert-butyl 3-(1-hydroxypropyl)benzoate
  参考文献：
  名称：

  Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors

  摘要：

  A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones was designed, synthesized, and evaluated as human chymase inhibitors. From this series, we identified several compounds which were effective, via oral administration, in a mouse model of chronic dermatitis. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.085

文献信息

• Methanofullerenes
  申请人：Robinson Alex Philip Graham

  公开号：US20140134843A1

  公开（公告）日：2014-05-15

  The present disclosure relates to novel methanofullerene derivatives, negative-type photoresist compositions prepared therefrom and methods of using them. The derivatives, their photoresist compositions and the methods are ideal for fine pattern processing using, for example, ultraviolet radiation, beyond extreme ultraviolet radiation, extreme ultraviolet radiation, X-rays and charged particle rays.

  本公开涉及新型甲烷富勒烯衍生物，由此制备的负型光刻胶组合物以及使用它们的方法。这些衍生物、它们的光刻胶组合物和方法非常适合使用紫外线辐射、超极紫外线辐射、极紫外线辐射、X射线和带电粒子束进行精细图案加工。
• FULLERENES
  申请人：ROBINSON Alex Philip Graham

  公开号：US20160139506A1

  公开（公告）日：2016-05-19

  The present disclosure relates to novel fullerene derivatives, positive and negative photoresist compositions prepared therefrom and methods of using them. The derivatives, their photoresist compositions and the methods are ideal for high speed, fine pattern processing using, for example, ultraviolet radiation, extreme ultraviolet radiation, beyond extreme ultraviolet radiation, X-rays, electron beam and other charged particle rays.

  本公开涉及新颖的富勒烯衍生物、由其制备的正、负光刻胶组合物及其使用方法。这些衍生物、光刻胶组合物和方法非常适合使用紫外辐射、极紫外辐射、超出极紫外辐射、X射线、电子束和其他带电粒子射线进行高速、精细图案处理。
• US9256126B2
  申请人：——

  公开号：US9256126B2

  公开（公告）日：2016-02-09
• US9632409B2
  申请人：——

  公开号：US9632409B2

  公开（公告）日：2017-04-25
• Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors
  作者：Hiroshi Maruoka、Tsuyoshi Muto、Taisaku Tanaka、Seiichi Imajo、Yoshiaki Tomimori、Yoshiaki Fukuda、Takashi Nakatsuka

  DOI：10.1016/j.bmcl.2007.03.085

  日期：2007.6

  A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones was designed, synthesized, and evaluated as human chymase inhibitors. From this series, we identified several compounds which were effective, via oral administration, in a mouse model of chronic dermatitis. (c) 2007 Elsevier Ltd. All rights reserved.