N-(1-(2-(1H-indol-3-yl)ethyl)-2-amino-1H-benzo[d]imidazol-5-yl)-4-pentylbenzamide hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(1-(2-(1H-indol-3-yl)ethyl)-2-amino-1H-benzo[d]imidazol-5-yl)-4-pentylbenzamide hydrochloride
• 英文别名: N-[2-amino-1-[2-(1H-indol-3-yl)ethyl]benzimidazol-5-yl]-4-pentylbenzamide;hydrochloride
• 化学式: C₂₉H₃₁N₅O*ClH
• 分子量: 502.059
• InChiKey: BNWWHIVFFWTZOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.75
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  88.7
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  溴化氰 、 在 盐酸 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 反应 16.0h， 生成 N-(1-(2-(1H-indol-3-yl)ethyl)-2-amino-1H-benzo[d]imidazol-5-yl)-4-pentylbenzamide hydrochloride
  参考文献：
  名称：

  2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium

  摘要：

  肠炎沙门氏菌中的一些血清型是全球最常见的食物和水传播病原体。

  DOI：

  10.1039/c8md00298c

文献信息

• SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS
  申请人：Ohio State Innovation Foundation

  公开号：EP3774740A2

  公开（公告）日：2021-02-17
• [EN] SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS<br/>[FR] ANALOGUES DE 2-AMINOBENZIMIDAZOLES SUBSTITUÉS UTILISÉS COMME AGENTS ANTI-BIOFILM
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2019195493A2

  公开（公告）日：2019-10-10

  In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.