2,6-Bis<2'-(chloromethyl)phenoxymethyl>pyridine | 165275-10-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-Bis<2'-(chloromethyl)phenoxymethyl>pyridine
• 英文别名: 2,6-bis[2-(chloromethylphenoxy)methyl]pyridine；2,6-Bis[[2-(chloromethyl)phenoxy]methyl]pyridine
• CAS: 165275-10-5
• 化学式: C₂₁H₁₉Cl₂NO₂
• 分子量: 388.293
• InChiKey: AEAPIQKNDAKKGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-Bis<2'-(chloromethyl)phenoxymethyl>pyridine 在 sodium tetrahydroborate 、 肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 3,19,27,43-tetraoxa-11,35,49,50-tetrazaheptacyclo[43.3.1.121,25.04,9.013,18.028,33.037,42]pentaconta-1(49),4,6,8,13,15,17,21(50),22,24,28,30,32,37,39,41,45,47-octadecaene
  参考文献：
  名称：

  Synthesis and crystal structure of a new large cryptand encapsulating a benzene molecule

  摘要：

  我们合成了两种新的大型隐色体 7a 和 7b，7b 的 X 射线结构证实，苯客体分子被包裹在其空腔的中心位置。

  DOI：

  10.1039/c39950000735
• 作为产物：
  描述：

  2,6-bis[(tosyloxy)methyl]pyridine 在 sodium tetrahydroborate 、 氯化亚砜 、 potassium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2,6-Bis<2'-(chloromethyl)phenoxymethyl>pyridine
  参考文献：
  名称：

  Cooperative Effect of Anion and Mole Ratio on the Coordination Modes of an NO₂S₃-Donor Macrocycle

  摘要：

  Synthesis of an NO2S3-macrocycle (L) incorporating a pyridine subunit and its anion and/or mole ratio-dependent coordination modes in the formations of mercury(II) complexes is reported. When the mercury(II) salts with different anions (ClO4- or Br-) were reacted with L, the Hg(ClO4)(2) afforded a typical endocyclic complex [HgL](ClO4)(2) (1). Meanwhile, the HgBr2 gave an exocyclic complex [HgLBr2] (2) in which the metal ion exists outside the macrocyclic cavity. The observed anion effect on the coordination modes can be explained by the anion coordination ability toward the metal cation. In the mole ratio variation experiments, notably, the use of 1.5 equiv or above of HgBr2 in the same reaction condition gave a unique endo/exocyclic dumbbell-type complex 3, [Hg4L2Br6][Hg2Br6]. However, the formation of the endocyclic Hg(ClO4)(2) complex 1 shows no mole ratio dependency. To monitor the observed mole ratio-dependent exocoordination products as well as their reactivities and reversibility, systematic powder X-ray diffraction (PXRD) analysis was also applied. From single crystal X-ray and PXRD analyses, it was found that endocyclic complex 1 is not reactive, but complexes 2 and 3 are reactive and show the reversibility between them in the presence of the corresponding reactants.

  DOI：

  10.1021/ic500594f

文献信息

• Synthesis of New Benzo-substituted Macrocyclic Ligands Containing Pyridine or Triazole as Subcyclic Units
  作者：Ahmed H.M Elwahy、Ashraf A Abbas

  DOI：10.1016/s0040-4020(99)01068-6

  日期：2000.2

  The macrocyclic diamides 11–21, 42 and 43 were prepared by nucleophilic reaction of the bis phenols 22–29 with the appropriate dihalo compounds 2, 3, 40 and 41, respectively. The macrocyclic dithiodiamides 30–33 were obtained in good yields upon treatment of 11, 13, 15 and 17 with Lawesson's reagent. The macrocycles 61–63 were prepared by condensation of the bis(aldehyde) 37 with the appropriate bis(aminotriazoles)

  大环二酰胺11 - 21，42和43是由双酚的亲核反应而制备22 - 29用适当的二卤代化合物2，3，40和41分别。大环dithiodiamides 30 - 33在处理后的良好的产率得到11，13，15和17与Lawesson试剂。大环61 – 63是通过双（醛）缩合制备的37用适当的双（氨基三唑）50 – 54生成相应的席夫碱56 – 60，然后用NaBH 4还原。
• Synthesis and crystal structure of a new large cryptand encapsulating a benzene molecule
  作者：Ronald J. A. Janssen、Leonard F. Lindoy、Owen A. Matthews、George V. Meehan、Alexander N. Sobolev、Allan H. White

  DOI：10.1039/c39950000735

  日期：——

  The synthesis of two new large cryptands 7a and 7b has been carried out and the X-ray structure of 7b confirms that a benzene guest molecule is encapsulated centrally in its cavity.

  我们合成了两种新的大型隐色体 7a 和 7b，7b 的 X 射线结构证实，苯客体分子被包裹在其空腔的中心位置。
• Sulfur-Containing Mixed-Donor Tribenzo-Macrocycles and Their Endo- and Exocyclic Supramolecular Silver(I) and Copper(I) Complexes
  作者：Eun-Ju Kang、So Young Lee、Hayan Lee、Shim Sung Lee

  DOI：10.1021/ic1007473

  日期：2010.8.16

  with the silver(I) salts (ClO4−, BF4−, and NO3−) afforded four complexes with different topologies: the exocyclic 1-D coordination polymer [Ag(L1)(ClO4)]n (1), the endocyclic 1:1 monomer complex [Ag(L2)]ClO4·CH3OH (2), the endo-/exocyclic 1-D coordination polymer [Ag2(L2)(CH3OH)](BF4)2}n (3), and the cyclic dimer complex [Ag2(L3)2(NO3)2]·2CH3CN (4). NMR titrations of L1 and L2 with silver(I) perchlorate

  新的含硫混合供电子大环大号1 -大号4用不同供体组和/或环大小（大号1，20元ö 3 š 2 ;大号2，20元NO 2小号2 ;大号3，20-元Ò 2小号3 ;和大号4，23元ö 4小号2合成），并通过X射线分析对其结构进行表征。报道了这些大环配体与银（I）盐和碘化铜（I）的配位行为的比较研究。七个复合物（X射线结构1 - 7已经确定，以及一系列结构类型和协调模式，包括单环至多核和内切经由M-S键的环外的人的，被示为发生）。在所有七个络合物中，每个环的醚氧是未结合的。的反应大号1 -大号4与银（I）盐（CLO 4 -，BF 4 - ，以及NO 3 -）提供了四种具有不同拓扑的配合物：环外一维配位聚合物[Ag（L 1）（ClO 4）] n（1），环内1：1单体配合物[Ag（L 2）] ClO 4 ·CH 3 OH（2），内/外环一维配位聚合物[Ag 2（L 2）（CH 3 OH）]（BF 4）2
• A double decker type complex: copper(<scp>i</scp>) iodide complexation with mixed donor macrocycles via [1 : 1] and [2 : 2] cyclisations
  作者：Yunji Kang、In-Hyeok Park、Mari Ikeda、Yoichi Habata、Shim Sung Lee

  DOI：10.1039/c5dt03751d

  日期：——

  A 38-membered macrocycle obtained from a [2 : 2] cyclisation reacts with CuI to form a double decker type complex which shows a sliding upon removal of the lattice solvents in an SCSC manner.

  一种由[2 : 2]环化反应得到的38元大环与CuI反应形成了一种双层型配合物，在SCSC方式下，当晶格溶剂被去除时，该配合物表现出滑动性质。
• Extra Large Macrocycle: 40-Membered Macrocycle via 2:2 Cyclization and Its Dimercury(II) Complex
  作者：Daram Jung、Rie Chamura、Yoichi Habata、Shim Sung Lee

  DOI：10.1021/ic2009607

  日期：2011.9.5

  A large 40-membered N(4)O(4)S(4) macrocyde (L(2)) was obtained through a 2:2 cyclization of the corresponding dithiol and dichloride as a minor product during the preparation of a 20-membered N(2)O(2)S(2) macrocycle (L(1), 1:1 cyclization product). Each macrocyde was successfully separated from the mixed products and identified. The larger macrocyde L(2) allowed the preparation of its dimercury(I) complex, adopting a one-dimensional (1D) stairway-like polymeric chain linked with the anion. A monomercury(II) complex of the smaller macrocyde L(1) was also prepared. Both complexes and the larger macrocyde L(2) were structurally characterized by the single crystal X-ray analysis.