6,8-二氧杂双环[3.2.1]辛烷 | 280-16-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 中文名称: 6,8-二氧杂双环[3.2.1]辛烷
• 英文名称: 6,8-dioxabicyclo<3.2.1>octane
• 英文别名: 6,8-dioxa-bicyclo[3.2.1]octane；6,8-Dioxa-bicyclo[3.2.1]octan；6,8-dioxabicyclo[3.2.1]octane；opt.-inakt. 6,8-Dioxa-bicyclo-<3,2,1>-octan；6,8-Dioxa-bicyclo-<3,2,1>-octan；6,8-Dioxa-bicyclo<3.2.1>octan
• CAS: 280-16-0
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: DYXJGWLSYLPWMO-UHFFFAOYSA-N

物化性质

• 熔点：
  50-52 °C
• 沸点：
  91.0-91.6 °C(Press: 100 Torr)
• 密度：
  1.086±0.06 g/cm3(Predicted)
• 稳定性/保质期：

  存在于主流烟气中。

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  6,8-二氧杂双环[3.2.1]辛烷 在 二叔丁基过氧化物 作用下， 以 various solvent(s) 为溶剂， 生成 C₆H₉O₂
  参考文献：
  名称：

  Kinetic applications of electron paramagnetic resonance spectroscopy. 36. Stereoelectronic effects in hydrogen atom abstraction from ethers

  摘要：

  DOI：

  10.1021/ja00393a018
• 作为产物：
  描述：

  5-oxohexanal 在 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 生成 6,8-二氧杂双环[3.2.1]辛烷
  参考文献：
  名称：

  饱和双环过氧化物的光解

  摘要：

  在直接光解下，[ n .2.1]-过氧化物（n = 3-5）主要异构化为环氧醛，[ n .2.2]-过氧化物（n = 2-4）主要经历脱氢反应生成环烷-1,4-二酮，以及2,3-二氧杂双环[2.2.1]庚烷表现出两种行为。当二苯甲酮作为敏化剂存在时，会发生6,7-向6,8-二氧杂双环[3.2.1]辛烷的光异构化。

  DOI：

  10.1016/s0040-4039(01)80203-3

文献信息

• [EN] THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF<br/>[FR] DÉRIVÉS DE THIÉNOPYRIMIDINE SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS D'ACC ET LEURS UTILISATIONS
  申请人：GILEAD SCIENCES INC

  公开号：WO2021030142A1

  公开（公告）日：2021-02-18

  The present disclosure relates generally to compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disase (NAFLD) and non-alcoholic steatohepatitis (NASH).

  本公开涉及一般与结合乙酰辅酶A羧化酶（ACC）并作为ACC的抑制剂的化合物有关。此外，本公开还涉及利用这些化合物制备药物以治疗通过结合ACC引起的疾病和/或状况，包括非酒精性脂肪肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）等肝病。
• Bicyclo-octane and bicyclo-nonane derivatives, processes for their preparation and their use as herbicides
  申请人：HER MAJESTY THE QUEEN IN RIGHT OF NEW ZEALAND, DEPARTMENT OF SCIENTIFIC AND INDUSTRIAL RESEARCH, CHEMISTRY DIVISON

  公开号：EP0302599A2

  公开（公告）日：1989-02-08

  Bicyclo-octane and bicyclo-nonane derivatives are described having herbicidal and plant growth regulating properties. The derivatives are based on the general formula

  双环辛烷和双环壬烷衍生物具有除草和植物生长调节性能。这些衍生物基于一般公式。
• METHOD FOR PRODUCING PLATE DENTURE, CURABLE STEREOLITHOGRAPHIC COMPOSITION, AND PLATE DENTURE PRODUCTION KIT
  申请人：Tokuyama Dental Corporation

  公开号：EP4091578A1

  公开（公告）日：2022-11-23

  [Object] To provide a method of producing a plate denture using a stereolithography 3D printer, which is capable of producing a plate denture in a short time with a more simplified production process, the plate denture exhibiting excellent occlusion. [Solving Means] The problem is solved by a method of producing a plate denture, including: adhering an artificial tooth and a denture base photochemically solidified by a stereolithography 3D printer to each other by polymerizing an unpolymerized curable composition for stereolithography present on a surface of the denture base. Further, stronger adhesion between the artificial tooth and the denture base is achieved by mixing, in the curable composition for stereolithography, a polymerization initiator other than a photopolymerization initiator for stereolithography.

  [目的]提供一种使用立体光刻3D打印机制作板式义齿的方法，该方法能够在短时间内制作出板式义齿，制作工艺更加简化，板式义齿具有良好的咬合效果。 [解决手段】本发明通过一种板式义齿的制作方法解决了上述问题，该方法包括：通过聚合存在于义齿基托表面的未聚合的立体光刻用可固化组合物，将人工牙和立体光刻3D打印机光化学固化的义齿基托相互粘附在一起。此外，通过在立体光刻用可固化组合物中混合立体光刻用光聚合引发剂以外的聚合引发剂，可实现人造牙齿和义齿基托之间更强的粘合力。
• Preparation of poly amidoimides
  申请人：Huntsman International LLC

  公开号：US10920019B2

  公开（公告）日：2021-02-16

  A liquid composition comprising (a) a solvent or solvent mixture containing at least 50% by weight, based on the total amount of solvents, of a dioxabicycloalkane derivative, (b) an aromatic tricarboxylic acid anhydride, and (c) an aromatic diisocyanate, can be used as coating composition for metal surfaces.

  一种液体组合物，包括 (a) 溶剂或溶剂混合物，其中二恶英二环烷烃衍生物的含量至少为溶剂总量的 50%（按重量计）、 (b) 一种芳香族三羧酸酸酐，和 (c) 一种芳香族二异氰酸酯、 可用作金属表面的涂层组合物。
• Thienopyrimidine derivatives as ACC inhibitors and uses thereof
  申请人：Gilead Sciences, Inc.

  公开号：US11352371B2

  公开（公告）日：2022-06-07

  The present disclosure relates generally to thienopyrimidine compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the thienopyrimidine compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

  本公开一般涉及与乙酰-CoA 羧化酶（ACC）结合并作为 ACC 抑制剂的噻吩嘧啶化合物。本公开进一步涉及噻吩嘧啶化合物用于制备通过与 ACC 结合治疗疾病和/或病症的药物，包括肝脏疾病，如非酒精性脂肪肝（NAFLD）和非酒精性脂肪性肝炎（NASH）。