(S)-(3-chlorophenyl)(4-methoxyphenyl)methanol | 1174327-73-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-(3-chlorophenyl)(4-methoxyphenyl)methanol
• 英文别名: (S)-(3-chlorophenyl)-(4-methoxyphenyl)methanol
• CAS: 1174327-73-1
• 化学式: C₁₄H₁₃ClO₂
• 分子量: 248.709
• InChiKey: LNBBNIDRDBLRME-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氯苯硼酸 、 4-甲氧基苯甲醛 在 chlorobis(ethylene)rhodium(I) dimer 、 (R)-2-[2'-(diphenylphosphino)-1,1'-binaphthyl-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol 、 sodium t-butanolate 作用下， 以 水 、 1,2-二氯乙烷 为溶剂， 反应 24.0h， 以73%的产率得到(S)-(3-chlorophenyl)(4-methoxyphenyl)methanol
  参考文献：
  名称：

  Novel Axially Chiral Phosphine Ligand with a Fluoro Alcohol Moiety for Rh-Catalyzed Asymmetric Arylation of Aromatic Aldehydes

  摘要：

  A new chiral phosphine ligand (R)-1 possessing a fluoroalcohol moiety was prepared. The (R)-1-coordinated Rh(I) complex showed an excellent catalytic activity for asymmetric 1,2-addition of arylboronic acids to aldehydes to afford highly enantioenriched diarylmethanols. The fluoroalcohol moiety in ligand (R)-1 plays a pivotal role for the high enantioselectivity of the present Rh(I)-catalyzed transformation.

  DOI：

  10.1021/ol100697a

文献信息

• Light-driven asymmetric coupling of aromatic aldehydes and aryl iodides using a simple amine reductant
  作者：Tongyu Han、Quansheng Mou、Yuyu Lv、Mingxin Liu

  DOI：10.1039/d3gc04014c

  日期：——

  by using a ‘greener’ yet less reactive reductant, a cobalt-catalyzed asymmetric reductive coupling reaction of aromatic aldehydes and aryl iodides has been developed with i-Pr2NEt as the reductant. A series of high-value-added chiral diaryl carbinols were afforded in high yields and enantioselectivities.

  为了通过使用“更绿色”但反应性较低的还原剂克服还原过程中的可持续性挑战，以i -Pr 2 NEt 作为还原剂开发了芳香醛和芳基碘化物的钴催化不对称还原偶联反应。以高产率和对映选择性提供了一系列高附加值的手性二芳基甲醇。
• Novel Axially Chiral Phosphine Ligand with a Fluoro Alcohol Moiety for Rh-Catalyzed Asymmetric Arylation of Aromatic Aldehydes
  作者：Satoshi Morikawa、Kyosuke Michigami、Hideki Amii

  DOI：10.1021/ol100697a

  日期：2010.6.4

  A new chiral phosphine ligand (R)-1 possessing a fluoroalcohol moiety was prepared. The (R)-1-coordinated Rh(I) complex showed an excellent catalytic activity for asymmetric 1,2-addition of arylboronic acids to aldehydes to afford highly enantioenriched diarylmethanols. The fluoroalcohol moiety in ligand (R)-1 plays a pivotal role for the high enantioselectivity of the present Rh(I)-catalyzed transformation.