4-(8-methoxycarbonyloctyloxy)benzaldehyde | 663157-48-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(8-methoxycarbonyloctyloxy)benzaldehyde
• 英文别名: Methyl 9-(4-formylphenoxy)nonanoate；methyl 9-(4-formylphenoxy)nonanoate
• CAS: 663157-48-0
• 化学式: C₁₇H₂₄O₄
• 分子量: 292.375
• InChiKey: MKDGIDCEOCVHSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(8-methoxycarbonyloctyloxy)benzaldehyde 在 manganese(IV) oxide 作用下， 以 甲醇 为溶剂， 反应 4.5h， 生成 methyl 9-[4-(4,4,5,5-tetramethyl-3-oxo-1-oxyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]nonanoate
  参考文献：
  名称：

  摘要：

  The synthesis of new donors and acceptors of nitrogen oxide is described. New lipophilic nitronylnitroxyl radicals (NNR) that act as paramagnetic scavengers of nitrogen oxide are synthesized and characterized. The purity of the preparations is determined, and their structures are confirmed. The lipophilicity of the radicals is tested by ESR spectroscopy. The incorporation into lipid multilayers is shown to protect NNR from reduction in biological samples, while their ability to scavenge nitrogen oxide and form iminonitroxyl radicals is retained. A decreased rate of NNR reduction under these conditions substantially enhances their effectiveness as paramagnetic acceptors of nitrogen oxide in biological systems. The synthesis of a new hydrophilic NO donor. 3-bromo-3,4-dihydro-4,4-dimethyl-3-(2-pyridyl)-diazet-1,2-dioxide (DDpyr) is described. The constants of DDpyr decomposition in tris-HCl buffer (pH 7.5) and in DMSO are determined (4.5 x 10(-6) and 0.5 x 10(-6) s(-1). respectively). A substantially higher rate of DDpyr decomposition in buffer, compared with the decomposition rates determined previously for some diazetines, makes DDpyr a prospective candidate for the use in aqueous media. It is found in experiments on perfused rat caudal artery that DDpyr is an effective vasodilator. Intraperitoneal injection of DDpyr to hereditarily hypertensive rats (ISIAH line) at doses of 100-200 mug/kg body mass considerably diminishe their systolic arterial pressure.

  DOI：

  10.1023/a:1024913620825

文献信息

• ——
  作者：V. I. Yelinova、A. A. Bobko、D. G. Mazhukin、A. L. Markel、V. V. Khramtsov

  DOI：10.1023/a:1024913620825

  日期：——

  The synthesis of new donors and acceptors of nitrogen oxide is described. New lipophilic nitronylnitroxyl radicals (NNR) that act as paramagnetic scavengers of nitrogen oxide are synthesized and characterized. The purity of the preparations is determined, and their structures are confirmed. The lipophilicity of the radicals is tested by ESR spectroscopy. The incorporation into lipid multilayers is shown to protect NNR from reduction in biological samples, while their ability to scavenge nitrogen oxide and form iminonitroxyl radicals is retained. A decreased rate of NNR reduction under these conditions substantially enhances their effectiveness as paramagnetic acceptors of nitrogen oxide in biological systems. The synthesis of a new hydrophilic NO donor. 3-bromo-3,4-dihydro-4,4-dimethyl-3-(2-pyridyl)-diazet-1,2-dioxide (DDpyr) is described. The constants of DDpyr decomposition in tris-HCl buffer (pH 7.5) and in DMSO are determined (4.5 x 10(-6) and 0.5 x 10(-6) s(-1). respectively). A substantially higher rate of DDpyr decomposition in buffer, compared with the decomposition rates determined previously for some diazetines, makes DDpyr a prospective candidate for the use in aqueous media. It is found in experiments on perfused rat caudal artery that DDpyr is an effective vasodilator. Intraperitoneal injection of DDpyr to hereditarily hypertensive rats (ISIAH line) at doses of 100-200 mug/kg body mass considerably diminishe their systolic arterial pressure.