6-(N'-methyl-ureido)-hexanoic acid | 98998-68-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(N'-methyl-ureido)-hexanoic acid
• 英文别名: 6-(N'-Methyl-ureido)-hexansaeure；6-(Methylcarbamoylamino)hexanoic acid
• CAS: 98998-68-6
• 化学式: C₈H₁₆N₂O₃
• 分子量: 188.227
• InChiKey: UNCYKPMXOFBHOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙醇 、 6-(N'-methyl-ureido)-hexanoic acid 在 盐酸 作用下， 生成 6-(N'-methyl-ureido)-hexanoic acid ethyl ester
  参考文献：
  名称：

  Amino Acids. V. 1,3-Di-(ι-carboxyalkyl)-thioureas and Their Chemistry

  摘要：

  DOI：

  10.1021/ja01539a058
• 作为产物：
  描述：

  6-氨基己酸 在 水 、 双氧水 、 硝酸 、 sodium nitrite 作用下， 生成 6-(N'-methyl-ureido)-hexanoic acid
  参考文献：
  名称：

  Amino Acids. V. 1,3-Di-(ι-carboxyalkyl)-thioureas and Their Chemistry

  摘要：

  DOI：

  10.1021/ja01539a058

文献信息

• Enteric elastomers
  申请人：Massachusetts Institute of Technology

  公开号：US11083690B2

  公开（公告）日：2021-08-10

  Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

  一般提供肠道弹性体和相关方法。在某些实施方案中，肠道弹性体是一种聚合物复合材料。某些实施方案包括一种聚合物复合材料，其中两种含羧基的聚合物内的氢键将聚合物网络交联成弹性和 pH 响应性聚合物复合材料。有利的是，这种聚合物复合材料在胃等酸性环境中具有稳定性和弹性，但在小肠和大肠等中性 pH 环境中可以溶解。在某些实施方案中，本文所述的聚合物复合材料包括两种或两种以上具有羧基官能团的聚合物的混合物，从而使两种或两种以上聚合物形成氢键。在某些实施方案中，聚合物复合材料同时具有肠道特性和弹性特性。
• ENTERIC ELASTOMERS
  申请人：Massachusetts Institute of Technology

  公开号：US20200030234A1

  公开（公告）日：2020-01-30

  Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.
• Amino Acids. V. 1,3-Di-(ι-carboxyalkyl)-thioureas and Their Chemistry
  作者：A. F. McKay、E. J. Tarlton、S. I. Petri、P. R. Steyermark、M. A. Mosley

  DOI：10.1021/ja01539a058

  日期：1958.3