methyl 3-(5-bromo-2-thienyl)-N-(tert-butoxycarbonyl)-L-alaninate | 959992-22-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 3-(5-bromo-2-thienyl)-N-(tert-butoxycarbonyl)-L-alaninate
• 英文别名: (S)-3-(5-bromo-thiophen-2-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester；methyl (2S)-3-(5-bromothiophen-2-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• CAS: 959992-22-4
• 化学式: C₁₃H₁₈BrNO₄S
• 分子量: 364.26
• InChiKey: JQPPZFDAUFVJIL-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  92.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 3-(5-bromo-2-thienyl)-N-(tert-butoxycarbonyl)-L-alaninate 、 4-戊炔-2-醇 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 以96%的产率得到methyl N-(tert-butoxycarbonyl)-3-[5-(4-hydroxypent-1-yn-1-yl)thiophen-2-yl]-L-alaninate
  参考文献：
  名称：

  N-[HETEROARYLCARBONYL]-3-THIENYL-L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS

  摘要：

  本发明涉及抑制a5b1功能的化合物，其制备方法，包含它们作为活性成分的制药组合物，它们作为药物的用途以及它们用于制造药物，用于治疗具有显著血管生成或血管组分的疾病，例如用于实体肿瘤的治疗。本发明还涉及a5b1拮抗剂，其也展示出对其他整合素适当的选择性剖面。

  公开号：

  US20080255183A1
• 作为产物：
  描述：

  (S)-N-BOC-2-(5-溴噻吩)苯胺 、 N,N-二异丙基乙胺 、 碘甲烷 、 水 在 乙酸乙酯 、 盐酸 、 disodium;carbonate 、 Sodium sulfate-III 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 以to furnish (S)-3-(5-bromo-thiophen-2-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester的产率得到methyl 3-(5-bromo-2-thienyl)-N-(tert-butoxycarbonyl)-L-alaninate
  参考文献：
  名称：

  Substituted azoanthracene derivatives and intermediates for preparation thereof

  摘要：

  本发明涉及取代的偶氮蒽衍生物及其制备中间体。这些取代的偶氮蒽衍生物和相关的中间体可用于制备药物组合物，用于治疗或预防调节人类GLP-1受体有益的疾病、疾病和状况。

  公开号：

  US09175003B2

文献信息

• PHENYLALANINE DERIVATIVES
  申请人：Arnould Jean-Claude

  公开号：US20080045521A1

  公开（公告）日：2008-02-21

  The present invention relates to compounds that inhibit of a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to a5b1 antagonists that also exhibit appropriate selectivity profile(s) against other integrins.

  本发明涉及抑制a5b1功能的化合物，其制备过程，含有其作为活性成分的制药组合物，以及它们作为药物在温血动物（如人类）中治疗具有明显血管生成或血管成分的疾病，例如固体肿瘤的制药用途。本发明还涉及a5b1拮抗剂，其还表现出对其他整合素的适当选择性特征。
• SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
  申请人：Mjalli Adnan M.M.

  公开号：US20110160198A1

  公开（公告）日：2011-06-30

  The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.

  本发明涉及替代的偶氮蒽衍生物或其药学上可接受的盐，其调节人类GLP-1受体，并可用于治疗调节人类GLP-1受体有益的疾病、紊乱或病症，如2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗调节人类GLP-1受体有益的这些疾病、紊乱或病症中的使用。
• Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof
  申请人：Mjalli Adnan M. M.

  公开号：US08383644B2

  公开（公告）日：2013-02-26

  The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.

  本发明涉及取代的偶氮蒽衍生物或其药学上可接受的盐，其调节人类GLP-1受体，并可在治疗调节人类GLP-1受体有益的疾病、疾病、或病情，如2型糖尿病。本发明还涉及包含这些化合物的制药组合物，以及在治疗这些有益的疾病、疾病或病情中使用这些化合物和组合物。
• Substituted Azoanthracene Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof
  申请人：TransTech Pharma, Inc

  公开号：US20130096150A1

  公开（公告）日：2013-04-18

  The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.

  本发明涉及取代的偶氮蒽衍生物或其药学上可接受的盐，其调节人类GLP-1受体并可用于治疗调节人类GLP-1受体有益的疾病、疾病或病状，例如2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及将这些化合物和组合物用于治疗这些有益的疾病、疾病或病状的用途。
• Substituted azoanthracene derivatives and intermediates for preparation thereof
  申请人：TransTech Pharma, LLC

  公开号：US09175003B2

  公开（公告）日：2015-11-03

  The present invention relates to substituted azoanthracene derivatives and intermediates for the preparation thereof. The substituted azoanthracene derivatives and associated intermediates may be useful for the preparation of pharmaceutical compositions for the treatment or prevention of diseases, disorders, and conditions wherein modulation of the human GLP-1 receptor is beneficial.

  本发明涉及取代的偶氮蒽衍生物及其制备中间体。这些取代的偶氮蒽衍生物和相关的中间体可用于制备药物组合物，用于治疗或预防调节人类GLP-1受体有益的疾病、疾病和状况。