N-chloro-1H-indole-3-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-chloro-1H-indole-3-sulfonamide
• 化学式: C₈H₇ClN₂O₂S
• 分子量: 230.67
• InChiKey: MWYBENGEKFEOPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND SELECTIVE TREATMENT OF CANCER
  申请人：Board of Regents of the University of Texas System

  公开号：US20180140578A1

  公开（公告）日：2018-05-24

  In one aspect, provided herein are methods for treating cancer in a subject, comprising: (1) identifying in the subject the presence of a mutation in a splicing factor selected from the group consisting of U2AF1, SF3B1, SRSF2, and ZRSR2; and/or determining in the subject an increased amount of DCAF15 compared to a control, and (2) inhibiting an activity of RBM39 in the subject. In some embodiments, the inhibiting step can include promoting RBM39 degradation, preferably in a DCAF15-dependent manner. Compositions are also provided.