6-(1-芘基)己酸 | 90936-85-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 中文名称: 6-(1-芘基)己酸
• 中文别名: 1-芘己酸
• 英文名称: 6-(1-pyrenyl)hexanoic acid
• 英文别名: 1-pyrenehexanoic acid；6-pyren-1-ylhexanoic acid
• CAS: 90936-85-9
• 化学式: C₂₂H₂₀O₂
• 分子量: 316.4
• InChiKey: NIFCSIAVYVXOTG-UHFFFAOYSA-N

物化性质

• 熔点：
  199-201 °C(lit.)
• 沸点：
  552.2±29.0 °C(Predicted)
• 密度：
  1.238±0.06 g/cm3(Predicted)
• 溶解度：
  在DMF中可溶
• 最大波长(λmax)：
  341nm, 325nm (MeOH)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38

反应信息

• 作为反应物：
  描述：

  6-(1-芘基)己酸 在 4-二甲氨基吡啶 、 ammonium hydroxide 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 [(E,6R,7S)-7-amino-6,8-dihydroxyoct-4-enyl] 6-pyren-1-ylhexanoate
  参考文献：
  名称：

  Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2

  摘要：

  Fluorescently labeled D-erythro-sphingosines have been successfully synthesized in 9 and 12 steps starting from commercially available Garner aldehyde. Determining the influence of the nature, position and linkage of the label on the in vitro phosphorylation rate by sphingosine kinases 1 and 2 resulted in the identification of a pyrene- and a NBD-labeled sphingosine which are both phosphorylated with efficiency comparable to the natural substrate. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.099
• 作为产物：
  描述：

  6-氯-6-氧代己酸乙酯 在 一水合肼 作用下， 生成 6-(1-芘基)己酸
  参考文献：
  名称：

  形成受激准分子的双发色分子中的基态二聚体：NMR和单光子计数数据。2.外消旋和内消旋二苯乙烯基戊烷和二苯乙烯基烷烃

  摘要：

  DOI：

  10.1021/j100373a036

文献信息

• Designing ratiometric fluorescent sensors for alkali metal ions from simple PET sensors by controlling spacer length
  作者：N. B. Sankaran、Seiichi Nishizawa、Masatoshi Watanabe、Tatsuya UchidaPresent address: School of Li、Norio Teramae

  DOI：10.1039/b500958h

  日期：——

  Sensing of alkali metal ions has attracted considerable interest owing to the significance of these metal ions in biology. Of the many mechanisms used for ion signaling, photoinduced electron transfer (PET) is the one most commonly exploited. We report the use of simple PET sensors as a ratiometric sensor towards alkali metal ions. The systems described here behave either as a simple PET sensor or as a ratiometric sensor towards alkali metal ions based on the length of the spacer that connects the donor and acceptor groups. The formation of an exciplex between the donor and acceptor groups in the metal ion free state and the changes of the monomer and the exciplex emissions on metal ion binding are utilized for the ratiometric signaling of alkali metal ions.

  由于碱金属离子在生物学中的重要性，碱金属离子的传感引起了人们极大的兴趣。在用于离子信号传导的多种机制中，光诱导电子转移（PET）是最常用的一种。我们报告了使用简单的 PET 传感器作为碱金属离子的比率传感器。这里描述的系统既可以作为简单的 PET 传感器，也可以作为基于连接供体和受体基团的间隔基长度的碱金属离子比率传感器。利用金属离子游离状态下的供体和受体基团之间激基复合物的形成以及单体的变化和金属离子结合上的激基复合物发射来用于碱金属离子的比率信号传导。
• RADIATION DOSIMETRY SOL OR GEL AND RADIATION DOSIMETER COMPRISING SAME AS MATERIAL FOR RADIATION DOSIMETRY
  申请人：Riken

  公开号：EP3686632A1

  公开（公告）日：2020-07-29

  There is provided a radiation dosimetry sol or gel, and a radiation dosimeter containing the sol or the gel as a material for radiation dosimetry. A radiation dosimetry sol or gel characterized by comprising a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; and a silicate salt (B). A radiation dosimetry sol or gel characterized by comprising a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; a silicate salt (B); a water-soluble organic polymer (C) having an organic acid salt structure or an organic acid anion structure; and a dispersant (D) for the silicate salt (B). A radiation dosimeter comprising, as a material for radiation dosimetry, the above-mentioned radiation dosimetry sol or gel.

  提供了一种辐射剂量测定溶胶或凝胶，以及一种含有该溶胶或凝胶作为辐射剂量测定材料的辐射剂量计。 一种辐射剂量测定溶胶或凝胶，其特征在于包含一种化合物 (A)，该化合物具有由水的辐射分解产物改变的激发光诱导荧光特性；以及一种硅酸盐 (B)。 一种辐射剂量计溶胶或凝胶，其特征在于包含一种化合物（A），该化合物具有受水的辐射分解产物影响而改变的激发光诱导荧光特性；一种硅酸盐（B）；一种具有有机酸盐结构或有机酸阴离子结构的水溶性有机聚合物（C）；以及一种用于硅酸盐（B）的分散剂（D）。 一种辐射剂量计，包括作为辐射剂量测定材料的上述辐射剂量测定溶胶或凝胶。
• Radiation dosimetry sol or gel and radiation dosimeter comprising same as material for radiation dosimetry
  申请人：RIKEN

  公开号：US11150358B2

  公开（公告）日：2021-10-19

  A radiation dosimetry sol or gel, and a radiation dosimeter containing the sol or the gel as a material for radiation dosimetry. A radiation dosimetry sol or gel including a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; and a silicate salt (B). A radiation dosimetry sol or gel including a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; a silicate salt (B); a water-soluble organic polymer (C) having an organic acid salt structure or an organic acid anion structure; and a dispersant (D) for the silicate salt (B). A radiation dosimeter including, as a material for radiation dosimetry, the above-mentioned radiation dosimetry sol or gel.

  一种辐射剂量测定溶胶或凝胶，以及一种含有该溶胶或凝胶作为辐射剂量测定材料的辐射剂量计。一种辐射剂量测定溶胶或凝胶，包括一种化合物 (A)，其激发光诱导荧光特性会因水的辐射分解产物而改变；以及一种硅酸盐 (B)。一种辐射剂量测定溶胶或凝胶，包括一种化合物（A），其激发光诱导荧光特性会因水的辐射分解产物而改变；一种硅酸盐（B）；一种水溶性有机聚合物（C），其具有有机酸盐结构或有机酸阴离子结构；以及一种用于硅酸盐（B）的分散剂（D）。一种辐射剂量计，包括作为辐射剂量测定材料的上述辐射剂量测定溶胶或凝胶。
• Method and apparatus for discovering, identifying and comparing biological activity mechanisms
  申请人：Cytoprint, Inc.

  公开号：US20020159625A1

  公开（公告）日：2002-10-31

  Provided herein are methods and devices for the assessment and identification of cellular biological activity mechanisms; the assessment and identification of the changes in cellular biological activity mechanisms caused by cellular perturbations; the assessment and identification of the cellular function, or biological activity mechanisms of genes and gene products and; and the identification of the many genes and their products that collectively act together in a biological mechanism.

  本文提供了用于评估和鉴定细胞生物活性机制的方法和装置；评估和鉴定由细胞扰动引起的细胞生物活性机制的变化；评估和鉴定基因和基因产物的细胞功能或生物活性机制；以及鉴定在生物机制中共同作用的许多基因及其产物。
• Aminoglycoside hybrids as potent RNA antagonists
  作者：Jeffrey B.-H. Tok、Junhyeong Cho、Robert R. Rando

  DOI：10.1016/s0040-4020(99)00240-9

  日期：1999.4

  Aminoglycosides specifically bind to the A-site decoding region of prokaryotic 16S rRNA with dissociation constants in the 1-2 mu M range. The aminoglycoside paromomycin binds to a truncated A-site construct with a K-d = 1.85 mu M. Paromomycin analogs are described here in which the aminoglycoside is linked via spacer groups to either thiazole orange or pyrene. These analogs bind specifically to the truncated A-site construct, but with affinities considerably higher than paromomycin itself. The binding of the hybrid molecules to the A-site is greater the shorter the spacer group. (C) 1999 Elsevier Science Ltd. All rights reserved.