(E)-N-Methyl-3-pentenamide | 142422-34-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-N-Methyl-3-pentenamide
• 英文别名: (E)-N-methylpent-3-enamide
• CAS: 142422-34-2
• 化学式: C₆H₁₁NO
• 分子量: 113.159
• InChiKey: FJKTYHBAFCZUAL-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苯甲醛 、 (E)-N-Methyl-3-pentenamide 在 polyphosphate ester 作用下， 反应 16.0h， 以30%的产率得到cis-5,6-Dihydro-1,5-dimethyl-6-phenyl-2(1H)-pyridinone
  参考文献：
  名称：

  Stereoselective syntheses of substituted 5,6-dihydro-2(1H)-pyridinones in polyphosphate media

  摘要：

  delta-Lactams have been synthesized with excellent stereocontrol of substituents by condensing 3-alkenamides with aryl aldehydes in polyphosphoric ester. The scope of the condensation of 3-alkenamides with aryl aldehydes in several phosphate media is examined, and a rationale is proposed regarding gamma-lactam versus delta-lactam formation.

  DOI：

  10.1021/jo00081a006
• 作为产物：
  描述：

  3-戊烯酰氯 、 甲胺 以 乙醚 为溶剂， 以50%的产率得到(E)-N-Methyl-3-pentenamide
  参考文献：
  名称：

  Stereoselective syntheses of substituted 5,6-dihydro-2(1H)-pyridinones in polyphosphate media

  摘要：

  delta-Lactams have been synthesized with excellent stereocontrol of substituents by condensing 3-alkenamides with aryl aldehydes in polyphosphoric ester. The scope of the condensation of 3-alkenamides with aryl aldehydes in several phosphate media is examined, and a rationale is proposed regarding gamma-lactam versus delta-lactam formation.

  DOI：

  10.1021/jo00081a006

文献信息

• INHIBITORS OF TYROSINE KINASES AND USES THEREOF
  申请人：JANKOWSKI Orion D.

  公开号：US20100035841A1

  公开（公告）日：2010-02-11

  Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.

  本文公开了抑制特定酪氨酸激酶活性的化合物。公开了制备这些化合物的方法。还公开了包括这些化合物的药物组合物。提供了使用所述化合物单独或与其他治疗剂联合治疗酪氨酸激酶介导的疾病或病症或酪氨酸激酶依赖性疾病或病症的方法。
• 4-ACYLAMINOPYRAZOLE DERIVATIVES
  申请人：Sankyo Company, Limited

  公开号：EP1329160A2

  公开（公告）日：2003-07-23

  A 4-acylaminopyrazole derivative represented by the following general formula: wherein R1 is a hydrogen atom, an optionally substituted C1-C16 alkyl group or the like,    R2 and R3 are independently a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group or the like, R4 is a hydrogen atom, a C1-C6 alkyl group or a cyano group, Z is an oxygen atom or a sulfur atom, Ar is an optionally substituted C6-C14 aryl group or an optionally substituted 5-6 membered unsaturated heterocyclic group, B is a hydrogen atom, a halogen atom, an optionally substituted C1-C16 alkyl group or the like.

  由以下通式代表的 4-酰氨基吡唑衍生物： 其中 R1 是氢原子、任选取代的 C1-C16 烷基或类似基团、 R2 和 R3 独立地为氢原子、卤素原子、任选取代的 C1-C6 烷基或类似基团、 R4 是氢原子、C1-C6 烷基或氰基、 Z 是氧原子或硫原子、 Ar 是任选取代的 C6-C14 芳基或任选取代的 5-6 位元不饱和杂环基团、 B 是氢原子、卤素原子、任选取代的 C1-C16 烷基或类似基团。
• Stereocontrolled syntheses of substituted unsaturated .delta.-lactams from 3-alkenamides
  作者：Charles M. Marson、Urszula Grabowska、Timothy Walsgrove

  DOI：10.1021/jo00045a001

  日期：1992.9

  Delta-Lactams have been synthesized with excellent stereocontrol of substituents by condensing 3-alkenamides with aryl aldehydes in polyphosphoric ester.
• POLYHYDROXYALKANOATE DERIVATIVES, PREPARATION AND USES THEREOF
  申请人：MICROMIDAS, INC.

  公开号：US20150148560A1

  公开（公告）日：2015-05-28

  Provided herein are methods that utilize polyhydroxyalkanoates (PHAs) as a substrate for further conversion to C4 and C5 compounds. Polyhydroxyalkanoates can undergo esterification to yield alkyl hydroxyalkanoates and alkyl alkenoates, which may serve as useful precursors in the production of alkadienes and alkenedioic acids, including for example butadiene and butenedioic acid.
• US8067395B2
  申请人：——

  公开号：US8067395B2

  公开（公告）日：2011-11-29