3,7-diphenyl-4,5,7,7a-tetrahydrofuro[2,3-c]pyran-2-one | 295780-15-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃吡喃类
• 英文名称: 3,7-diphenyl-4,5,7,7a-tetrahydrofuro[2,3-c]pyran-2-one
• 英文别名: 3,7-Diphenyl-4,5,7,7a-tetrahydro-2H-furo[2,3-c]pyran-2-one
• CAS: 295780-15-3
• 化学式: C₁₉H₁₆O₃
• 分子量: 292.334
• InChiKey: ZJOQZAKNFTYYQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 K{HB(i-Pr)3} 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 以20.9%的产率得到3,7-diphenyl-4,5,7,7a-tetrahydrofuro[2,3-c]pyran-2-one
  参考文献：
  名称：

  Reaction of nucleophiles with alkoxycarbene complexes of chromium: a general access to polycyclic substituted butenolides

  摘要：

  A series of new substituted butenolides has been obtained either by reacting alkynylalkoxycarbene complexes 3 with simple nucleophiles such as metal hydrides, metal alkoxides and metal alkyls, or by reacting simple alkoxycarbene complexes 6 with more elaborate nucleophiles such as metal alkynolates or metal alkynyls. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01284-4

文献信息

• A Major Breakthrough in the Use of Alkoxycarbene Complexes of Chromium and Tungsten for the Synthesis of Elaborate Organic Compounds: Dihydropyridine Induced Reductions and Cascade Insertion Reactions
  作者：H. Rudler、A. Parlier、T. Durand-Réville、B. Martin-Vaca、M. Audouin、E. Garrier、V. Certal、J. Vaissermann

  DOI：10.1016/s0040-4020(00)00214-3

  日期：2000.7

  Alkoxy (alkyl)carbene complexes of tungsten and chromium react with dihydropyridine and N-methyldihydropyridine to give respectively pyridinium ylid complexes and N-methylpyridinium tungstates and chromates. These two types of complexes can be used, for the former, as cyclopropanation reagents, for the latter, as unprecedented initiators of cascade multiinsertions of olefins, alkynes and CO. These

  钨和铬的烷氧基（烷基）卡宾配合物与二氢吡啶并反应Ñ -methyldihydropyridine分别得到吡啶鎓内鎓盐配合物和Ñ -methylpyridinium钨酸盐和铬酸盐。前者可将这两种类型的配合物用作环丙烷化试剂，后者可将其用作史无前例的烯烃，炔烃和CO级联多插入物的引发剂。这些插入可形成复杂的多环化合物。
• Enantioselective approach to butenolides upon reduction of alkoxycarbene complexes of chromium with chiral dihydropyridines
  作者：Henri Rudler、Andrée Parlier、Victor Certal、Jean-Cedric Frison

  DOI：10.1016/s0040-4039(01)00997-2

  日期：2001.7

  Chromium alkoxycarbene complexes tethered to a triple bond react with a series of chiral dihydropyridines, among which is N-methyl-1,2-dihydronicotine, to give enantioselectively, upon cascade insertion reactions, polycyclic butenolides. (C) 2001 Elsevier Science Ltd. Air rights reserved.
• Reaction of nucleophiles with alkoxycarbene complexes of chromium: a general access to polycyclic substituted butenolides
  作者：Henri Rudler、Andrée Parlier、Victor Certal、Nadège Humbert、Jacqueline Vaissermann

  DOI：10.1016/s0040-4039(02)01284-4

  日期：2002.8

  A series of new substituted butenolides has been obtained either by reacting alkynylalkoxycarbene complexes 3 with simple nucleophiles such as metal hydrides, metal alkoxides and metal alkyls, or by reacting simple alkoxycarbene complexes 6 with more elaborate nucleophiles such as metal alkynolates or metal alkynyls. (C) 2002 Elsevier Science Ltd. All rights reserved.