pyriplatin | 106343-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: pyriplatin
• 英文别名: cDPCP；cis-diammine(pyridine)chloroplatinum(II) chloride；cis-[Pt(NH₃)₂(pyridine)Cl]Cl；cis-[Pt(NH₃)₂(Py)Cl]Cl；cDPCP, >=98% (HPLC), solid；azane;chloroplatinum(1+);pyridine;chloride
• CAS: 106343-59-3；106343-54-8；23360-98-7
• 化学式: C₅H₁₁ClN₃Pt*Cl
• 分子量: 379.148
• InChiKey: JDWBOMGRVMIMAU-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.59
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  14.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  pyriplatin 在 盐酸 作用下， 以 盐酸 为溶剂， 生成 trans-(ammine-pyridine)-dichloro-platinum(II) 、 {PtCl4}*{PtCl2}
  参考文献：
  名称：

  251.一些氯化铂胺的结构

  摘要：

  DOI：

  10.1039/jr9330001056
• 作为产物：
  描述：

  tetrammineplatinum(II) chloride 、 {Pt}2{PtCl4} 以 水 为溶剂， 生成 pyriplatin
  参考文献：
  名称：

  251.一些氯化铂胺的结构

  摘要：

  DOI：

  10.1039/jr9330001056

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Pt: MVol.D, 89, page 211 - 213
  作者：

  DOI：——

  日期：——
• The reaction of a platinated methionine motif of CTR1 with cysteine and histidine is dependent upon the type of precursor platinum complex
  作者：Guolin Ma、Qin Wu、Xuelei Wu、Fabio Arnesano、Giovanni Natile、Einar Sletten、Yangzhong Liu

  DOI：10.1016/j.jinorgbio.2015.07.010

  日期：2015.12

  The human copper protein (hCTR1) is believed to facilitate the cellular uptake of cisplatin. Cisplatin likely binds to the methionine (Met)-rich motifs located in the N-terminus of hCTR1, and ligand exchange would be essential if cisplatin has to pass through the hCTR1 channel. In this work, we investigated the reaction between platinated adducts of a methionine-rich motif of yeast CTR1 (Mets7) and N-acetyl-cysteine (AcCys) or N-acetyl-histidine (AcHis), mimicking metal-binding residues downstream the CTR1 channel. Platination involved two cis-compounds, cisplatin and oxaliplatin, and one monofunctional complex, cisdiammine(pyridine)chloridoplatinum(II) (cDPCP). The reactions were monitored by HPLC and the products were characterized by ESI-MS. The results indicate different reactivities depending upon the platinum complex. The cisplatin/Mets7 adduct reacts readily with both cysteine and histidine (t(1/2) < 2 min). In contrast, the oxaliplatin/Mets7 adduct reacts with cysteine but not with histidine, whereas cDPCP/Mets7 adduct reacts with histidine but not with cysteine. Hence, Mets7 adducts of these platinum complexes exhibit different reactivities towards downstream coordinating amino acids. These results suggest that each platinum complex possesses different reactivities and consequently may lead to differences in their cellular distribution and bioactivity. (C) 2015 Elsevier Inc. All rights reserved.
• Transport of platinum bonded nucleotides into proteoliposomes, mediated by Drosophila melanogaster thiamine pyrophosphate carrier protein (DmTpc1)
  作者：Chiara Carrisi、Daniela Antonucci、Paola Lunetti、Danilo Migoni、Chiara R. Girelli、Vincenza Dolce、Francesco P. Fanizzi、Michele Benedetti、Loredana Capobianco

  DOI：10.1016/j.jinorgbio.2013.09.012

  日期：2014.1

  The results of the present study suggest that DmTpc1 is actively implicated in the specific uptake of free cytoplasmic Pt bonded nucleotides, and therefore could be linked to the mechanism of action of some platinum-based antitumor drugs. Although DmTpc1 has a low affinity for model [Pt(dien)(N7-5'-dGTP)] and cis-(Pt(NH3)(2)(py)(N7-5'-dGTP)] compared to dATP it's well known that DNA platination level of few metal atoms per double-stranded molecule may account for the pharmacological activity of platinum based antitumor drugs. This is the first investigation where it has been demonstrated that a mitochondrial carrier is directly involved in the transport of metalated purines related with the cisplatin mechanism of action. Moreover it is shown as a lower hindrance of nucleotide bonded platinum complexes could strongly enhance mitochondrial uptake. Furthermore, a new application of ICP-AES addressed to measure the transport of metalated nucleobases, by using a recombinant protein reconstituted into liposomes, has been here, for the first time, developed and compared with a standard technique such as the liquid scintillation counting. (C) 2013 Elsevier Inc. All rights reserved.
• 251. The structure of some ammines of platinous chloride
  作者：F. W. Pinkard、H. Saenger、W. Wardlaw

  DOI：10.1039/jr9330001056

  日期：——