cyclo(Arg-Phe) | 74838-84-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cyclo(Arg-Phe)
• 英文别名: N''-{3-[(2S,5S)-5-Benzyl-3,6-dioxopiperazin-2-yl]propyl}guanidine；2-[3-[(2S,5S)-5-benzyl-3,6-dioxopiperazin-2-yl]propyl]guanidine
• CAS: 74838-84-9
• 化学式: C₁₅H₂₁N₅O₂
• 分子量: 303.364
• InChiKey: CAKBEMYCCHKGSU-RYUDHWBXSA-N

物化性质

• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  123
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  BOC-L-苯丙氨酸 、 N-Boc-L-精氨酸 以72%的产率得到cyclo(Arg-Phe)
  参考文献：
  名称：

  A facile pathway to synthesize diketopiperazine derivatives

  摘要：

  Eighteen diketopiperazines (DKPs) were synthesized in good yields by a solid-phase protocol. This synthesis reveals that the OPac linker between the peptidyl and resin support is favorable to DKP-ring formation and offers a facile and effective way to prepare diverse DKP libraries for combinatorial chemistry. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02005-6

文献信息

• A facile pathway to synthesize diketopiperazine derivatives
  作者：De-Xin Wang、Ming-Tao Liang、Gui-Jie Tian、Hao Lin、Hong-Qiang Liu

  DOI：10.1016/s0040-4039(01)02005-6

  日期：2002.1

  Eighteen diketopiperazines (DKPs) were synthesized in good yields by a solid-phase protocol. This synthesis reveals that the OPac linker between the peptidyl and resin support is favorable to DKP-ring formation and offers a facile and effective way to prepare diverse DKP libraries for combinatorial chemistry. (C) 2002 Elsevier Science Ltd. All rights reserved.