3-(3-methylbutan-2-yl)-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(3-methylbutan-2-yl)-1H-indole
• 化学式: C₁₃H₁₇N
• 分子量: 187.28
• InChiKey: OJDIXQMNVQGMQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

文献信息

• IRAK DEGRADERS AND USES THEREOF
  申请人：Kymera Therapeutics, Inc.

  公开号：US20190192668A1

  公开（公告）日：2019-06-27

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用这些化合物的方法。
• POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS
  申请人：TRANSLATE BIO, INC.

  公开号：US20200277446A1

  公开（公告）日：2020-09-03

  Disclosed are polymers comprising the moiety A, which is a moiety of formula I: and pharmaceutically acceptable salts thereof, wherein R, R 1 , R 2 , L, n1 and n2 are as defined herein. These polymers are useful for delivering nucleic acids to subject. These polymers and pharmaceutically acceptable compositions comprising such polymers and nucleic acids can be useful for treating various diseases, disorders and conditions.

  揭示了包含A基团的聚合物，该基团是化学式I的基团：及其药用可接受的盐，其中R、R1、R2、L、n1和n2如本文所定义。这些聚合物对于将核酸传递给受试者是有用的。这些聚合物和包含这些聚合物和核酸的药用可接受组合物可用于治疗各种疾病、疾病和症状。
• FIVE-MEMBERED HETEROCYCLIC OXOCARBOXYLIC ACID COMPOUND AND MEDICAL USE THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP4053124A1

  公开（公告）日：2022-09-07

  The present invention relates to a five-membered heterocyclic oxocarboxylic acid compound and the medical use thereof. Specifically, the present invention relates to a compound as represented by formula (I) and a pharmaceutically acceptable salt, prodrug, hydrate, solvate or crystal form thereof, and also relates to a method for preparing the compound, a pharmaceutical composition containing the compound, and the medical use thereof as a secretion regulator of type I interferon, especially as a STING agonist, and in the preparation of a drug for preventing and/or treating diseases related to type I interferon.

  本发明涉及一种五元杂环氧化羧酸化合物及其医疗用途。具体地说，本发明涉及一种由式（I）表示的化合物及其药学上可接受的盐、原药、水合物、溶液或晶体形式，还涉及一种制备该化合物的方法、一种含有该化合物的药物组合物，以及其作为 I 型干扰素分泌调节剂，特别是作为 STING 激动剂，以及在制备预防和/或治疗与 I 型干扰素相关疾病的药物中的医学用途。
• IRAK degraders and uses thereof
  申请人：Kymera Therapeutics, Inc.

  公开号：US10874743B2

  公开（公告）日：2020-12-29

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用方法。
• Poly(phosphoesters) for delivery of nucleic acids
  申请人：TRANSLATE BIO, INC.

  公开号：US11530298B2

  公开（公告）日：2022-12-20

  Disclosed are polymers comprising the moiety A, which is a moiety of formula I: and pharmaceutically acceptable salts thereof, wherein R, R 1 , R 2 , L, n1 and n2 are as defined herein. These polymers are useful for delivering nucleic acids to subject. These polymers and pharmaceutically acceptable compositions comprising such polymers and nucleic acids can be useful for treating various diseases, disorders and conditions.

  本发明公开了包含分子 A 的聚合物（分子 A 为式 I 的分子）及其药学上可接受的盐类，其中 R、R 1 , R 2 、L、n1 和 n2 如本文所定义。这些聚合物可用于向受试者提供核酸。这些聚合物以及包含此类聚合物和核酸的药学上可接受的组合物可用于治疗各种疾病、失调和病症。