6-(4-甲基苯基)-2-氧代-5-苯基-1H-吡啶-3-腈 | 616870-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 6-(4-甲基苯基)-2-氧代-5-苯基-1H-吡啶-3-腈
• 英文名称: 2-oxo-6-(4-methylphenyl)-5-phenylnicotinonitrile
• 英文别名: 6-(4-methylphenyl)-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile；6-(4-methylphenyl)-2-oxo-5-phenyl-1H-pyridine-3-carbonitrile
• CAS: 616870-22-5
• 化学式: C₁₉H₁₄N₂O
• 分子量: 286.333
• InChiKey: IMHRCFKDCZJONL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(4-甲基苯基)-2-氧代-5-苯基-1H-吡啶-3-腈 在 三氯氧磷 作用下， 以90%的产率得到2-chloro-6-(4-methylphenyl)-5-phenylnicotinonitrile
  参考文献：
  名称：

  Rapid assembly of diverse and potent allosteric Akt inhibitors

  摘要：

  This paper describes the rapid assembly of four different classes of potent Akt inhibitors from a common intermediate. Among them, a pyridopyrimidine series displayed the best intrinsic and cell potency against Akt1 and Akt2. This series also showed a promising pharmacokinetic pro. le and excellent selectivity over other closely related kinases. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2007.10.023
• 作为产物：
  描述：

  3-氧代-2-苯基-3-(4-甲基苯基)丙醛 在 ammonium acetate 、 溶剂黄146 、 N,N-二甲基甲酰胺 、 三氯氧磷 作用下， 反应 28.0h， 生成 6-(4-甲基苯基)-2-氧代-5-苯基-1H-吡啶-3-腈
  参考文献：
  名称：

  Synthesis of 2-hydroxy-5,6-diarylnicotinonitriles and 2-chloro-5,6-diarylnicotinonitriles from β-chloroenones

  摘要：

  Vilsmeier-Haack reaction of beta-ketoaldehydes leads to the formation of beta-chloroenones and these chloroenones on treatment with malononitrile afford 2-hydroxy-5,6-diarylnicotinonitriles. But a one-pot reaction of beta-ketoaldehydes with Vilsmeier-Haack reagent and malononitrile or cyanoacetamide results in the formation of 2-chloro-5,6-diarylnicotinonitriles in good yields. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.07.031

文献信息

• Inhibitors of akt activity
  申请人：Bilodeau T. Mark

  公开号：US20050222155A1

  公开（公告）日：2005-10-06

  The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

  本发明涉及化合物，其中包含2,3-二苯基喹喔啉基团，该基团能够抑制Akt，一种丝氨酸/苏氨酸蛋白激酶的活性。本发明还涉及包含本发明化合物的化疗组合物以及治疗癌症的方法，包括给予本发明化合物的治疗方法。
• Inhibitors of Akt Activity
  申请人：Bilodeau T. Mark

  公开号：US20070254901A1

  公开（公告）日：2007-11-01

  The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

  本发明涉及含有取代的5-脱氨嘌呤基团的化合物，该化合物抑制Akt蛋白激酶的活性。该发明还涉及含有本发明化合物的化疗组合物以及治疗癌症的方法，包括给予本发明化合物的治疗方法。
• Inhibitors of Akt activity
  申请人：Merck & Co., Inc.

  公开号：US07223738B2

  公开（公告）日：2007-05-29

  The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

  本发明涉及一种化合物，其中包含2,3-二苯基喹啉基团，可抑制Akt，一种丝氨酸/苏氨酸蛋白激酶的活性。本发明还涉及含有该发明化合物的化疗组合物以及治疗癌症的方法，包括给予该发明化合物。
• [EN] INHIBITORS OF AKT ACTIVITY<br/>[FR] INHIBITEURS DE L'ACTIVITE DE AKT
  申请人：MERCK & CO INC

  公开号：WO2006036395A3

  公开（公告）日：2007-12-21
• INHIBITORS OF AKT ACTIVITY
  申请人：Merck & Co., Inc.

  公开号：EP1496896A1

  公开（公告）日：2005-01-19