RJC 04102

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: RJC 04102
• 英文别名: 1-[3-(2,4-Dichlorophenyl)-5-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]ethanone
• 化学式: C₁₇H₁₄Cl₂N₂O₂
• 分子量: 349.216
• InChiKey: KMCTZTBEJZNCJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (E)-3-(2,4-dichlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 、 溶剂黄146 在 一水合肼 作用下， 反应 24.0h， 生成 RJC 04102
  参考文献：
  名称：

  Anti-inflammatory, analgesic and antipyretic N-acetyl-Δ2-pyrazolines and dihydrothienocoumarines

  摘要：

  1-Acetyl-3-(2-hydroxyphenyl)-5-(RR'-aryl)-4,5-dihydro-(1H)pyrazoles (2a-o) were synthesized and showed anti-inflammatory and analgesic activity. The substituents on the 5-aryl group were necessary for biological activity. R-R'-aryl-2-dihydro-1,2(4H)thieno(2,3-c)benzo(e)pyranone-4 derivatives (3a-f) also showed analgesic and anti-inflammatory activity. The position and the number of the substituents caused a modulation of analgesic or anti-inflammatory activity of the N-acetyl-DELTA2-pyrazoline 2 and dihydrothienocoumarines 3. All compounds showed low antipyretic activity.

  DOI：

  10.1016/0223-5234(92)90142-n

文献信息

• AGENTS AND METHODS FOR TREATING ISCHEMIC AND OTHER DISEASES
  申请人：Sun Xiujun

  公开号：US20110251182A1

  公开（公告）日：2011-10-13

  This invention relates to methods of screening for modulators of mammalian cell injury cause by TRPM7 gene and protein activity, compounds that modulate TRPM7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of TRPM7 gene and protein activity.
• US9566284B2
  申请人：——

  公开号：US9566284B2

  公开（公告）日：2017-02-14
• Anti-inflammatory, analgesic and antipyretic N-acetyl-Δ2-pyrazolines and dihydrothienocoumarines
  作者：F Manna、F Chimenti、A Bolasco、ML Cenicola、M D'Amico、C Parrillo、F Rossi、E Marmo

  DOI：10.1016/0223-5234(92)90142-n

  日期：1992.9

  1-Acetyl-3-(2-hydroxyphenyl)-5-(RR'-aryl)-4,5-dihydro-(1H)pyrazoles (2a-o) were synthesized and showed anti-inflammatory and analgesic activity. The substituents on the 5-aryl group were necessary for biological activity. R-R'-aryl-2-dihydro-1,2(4H)thieno(2,3-c)benzo(e)pyranone-4 derivatives (3a-f) also showed analgesic and anti-inflammatory activity. The position and the number of the substituents caused a modulation of analgesic or anti-inflammatory activity of the N-acetyl-DELTA2-pyrazoline 2 and dihydrothienocoumarines 3. All compounds showed low antipyretic activity.