3-(2-methylpropyl)-9H-carbazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(2-methylpropyl)-9H-carbazole
• 化学式: C₁₆H₁₇N
• 分子量: 223.31
• InChiKey: PRBDEIRYRGYEMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

文献信息

• Neuroprotective agents for treatment of neurodegenerative diseases
  申请人：WAYNE STATE UNIVERSITY

  公开号：US10874669B2

  公开（公告）日：2020-12-29

  A compound having formula IA is useful for treating a neurodegenerative disease: or a pharmaceutically acceptable salt or ester thereof, where R0, R1, R2, R7, R8 are delineated substituents; A1 is a C6-12 aryl group, C5-12 heteroaryl group, substituted 3-hydroxypyridin-4(1H)-one, with i hydrogen atoms replaced with R7 and j hydrogen atoms replaced with R8; p is an integer from 1 to 6; X1, Y1 are each independently CH or N; M is absent or a divalent linking moiety in which Z is repeated m times; m is an integer from 0 to 5; i, j are each independently 0, 1, 2, or 3; and o is 0, 1, 2, 3, or 4.

  具有式 IA 的化合物可用于治疗神经退行性疾病： 或其药学上可接受的盐或酯，其中 R0、R1、R2、R7、R8 是划定的取代基；A1 是 C6-12 芳基、C5-12 杂芳基、取代的 3-羟基吡啶-4(1H)-酮，其中 i 个氢原子被 R7 取代，j 个氢原子被 R8 取代； p 为 1-6 的整数；X1、Y1 各自独立地为 CH 或 N；M 不存在或为二价连接基团，其中 Z 重复 m 次；m 为 0-5 的整数；i、j 各自独立地为 0、1、2 或 3；以及 o 为 0、1、2、3 或 4。
• INHIBITORS OF PROTEIN KINASES
  申请人：PORTOLA PHARMACEUTICALS, INC.

  公开号：US20180186783A1

  公开（公告）日：2018-07-05

  The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
• NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：WAYNE STATE UNIVERSITY

  公开号：US20190038622A1

  公开（公告）日：2019-02-07

  A compound having formula IA is useful for treating a neurodegenerative disease: or a pharmaceutically acceptable salt or ester thereof, where R 0 , R 1 , R 2 , R 7 , R 8 are delineated substituents; A 1 is a C 6-12 aryl group, C 5-12 heteroaryl group, substituted 3-hydroxypyridin-4(1H)-one, with i hydrogen atoms replaced with R 7 and j hydrogen atoms replaced with R 8 ; p is an integer from 1 to 6; X 1 , Y 1 are each independently CH or N; M is absent or a divalent linking moiety in which Z is repeated m times; m is an integer from 0 to 5; i, j are each independently 0, 1, 2, or 3; and o is 0, 1, 2, 3, or 4.
• US9902688B2
  申请人：——

  公开号：US9902688B2

  公开（公告）日：2018-02-27