6-(苄氧基)吡啶-2-胺 | 1174626-28-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 6-(苄氧基)吡啶-2-胺
• 英文名称: 6-(benzyloxy)pyridin-2-amine
• 英文别名: 2-Amino-6-benzyloxypyridine；6-phenylmethoxypyridin-2-amine
• CAS: 1174626-28-8
• 化学式: C₁₂H₁₂N₂O
• 分子量: 200.24
• InChiKey: MEPQJQHIUFFWMI-UHFFFAOYSA-N

物化性质

• 沸点：
  357.6±27.0 °C(Predicted)
• 密度：
  1.180±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  6-(苄氧基)吡啶-2-胺 在 乙醇 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 生成 (R)-1-((6-(benzyloxy)pyridin-2-yl)amino)-3-((2-hydroxyethyl)amino)propan-2-ol
  参考文献：
  名称：

  NOVEL P62 LIGAND COMPOUND, AND COMPOSITION CONTAINING SAME FOR PREVENTING, AMELIORATING, OR TREATING PROTEINOPATHIES

  摘要：

  Novel p62 ligand compounds, or a stereoisomer, a solvate, a hydrate, or a prodrug thereof are disclosed. The novel compounds, stereoisomer, solvate, hydrate, or prodrug activates selective autophagy in cells to selectively remove proteins, organelles, and coagulations in the body, and thus can be advantageously used as a pharmaceutical composition for preventing, ameliorating, or treating various proteinopathies. Compositions such as pharmaceutical composition or food compositions containing the novel p62 ligand compounds, stereoisomer, solvate, hydrate, or prodrug thereof as well as uses thereof are disclosed.

  公开号：

  US20220402873A1
• 作为产物：
  描述：

  N-(6-(benzyloxy)pyridin-2-yl)acetamide 在 甲醇 、 sodium hydroxide 作用下， 以4.7 g的产率得到6-(苄氧基)吡啶-2-胺
  参考文献：
  名称：

  NOVEL P62 LIGAND COMPOUND, AND COMPOSITION CONTAINING SAME FOR PREVENTING, AMELIORATING, OR TREATING PROTEINOPATHIES

  摘要：

  Novel p62 ligand compounds, or a stereoisomer, a solvate, a hydrate, or a prodrug thereof are disclosed. The novel compounds, stereoisomer, solvate, hydrate, or prodrug activates selective autophagy in cells to selectively remove proteins, organelles, and coagulations in the body, and thus can be advantageously used as a pharmaceutical composition for preventing, ameliorating, or treating various proteinopathies. Compositions such as pharmaceutical composition or food compositions containing the novel p62 ligand compounds, stereoisomer, solvate, hydrate, or prodrug thereof as well as uses thereof are disclosed.

  公开号：

  US20220402873A1

文献信息

• ANTIPROLIFERATIVE COMPOUNDS AND CONJUGATES MADE THEREFROM
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20180110873A1

  公开（公告）日：2018-04-26

  A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.

  一种能够抑制细胞增殖的化合物，其结构符合以下公式（I） 其中公式（I）中的变量如规范中所定义。这些化合物可用作抗癌药物，特别是在抗体药物结合物中。
• Metal- and base-free synthesis of imidazo[1,2-<i>a</i>]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes
  作者：Jing Tan、Penghui Ni、Huawen Huang、Guo-Jun Deng

  DOI：10.1039/c8ob00981c

  日期：——

  The elemental sulfur-promoted oxidative cyclization reaction for the efficient synthesis of substituted imidazo[1,2-a]pyridines has been developed. Easily available 2-aminopyridines and aldehydes were directly assembled in a highly atom-economical fashion through oxidative annulation under metal- and base-free conditions. Besides arylacetaldehydes, aliphatic aldehydes were also compatible with this

  已经开发出用于有效合成取代的咪唑并[1,2- a ]吡啶的元素硫促进的氧化环化反应。容易获得的2-氨基吡啶和醛类在无金属和无碱条件下通过氧化环化法以高度原子经济的方式直接组装。除芳基乙醛外，脂族醛也与该体系相容，以具有克级合成能力的优异收率递送烷基取代的咪唑并[1,2- a ]吡啶。
• Novel N-formyl hydroxylamine compounds, compositions and methods of use
  申请人：——

  公开号：US20030045479A1

  公开（公告）日：2003-03-06

  N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylamino-aryl or -heteroaryl)-azacyclo 4-7 alkanes or thiazacyclo 4-7 alkanes or imidazacyclo 4-7 alkanes have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections.

  N-[1-氧代-2-烷基-3-(N-羟基甲酰胺基)-丙基]-(羰基氨基-芳基或-杂环芳基)-氮杂环4-7烷烃或硫氮杂环4-7烷烃或咪唑氮杂环4-7烷烃具有有趣的特性，例如在治疗或预防适合使用肽变形酶抑制剂治疗的疾病，如细菌感染的治疗。
• AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
  申请人：Bahmanyar Sogole

  公开号：US20100093698A1

  公开（公告）日：2010-04-15

  Provided herein are Heteroaryl Compounds of formula (I): wherein R 1 and R 2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

  本文提供了公式（I）的杂环芳基化合物：其中R1和R2如本文所定义，包含有效量杂环芳基化合物的组合物，以及用于治疗或预防炎症性疾病或癌症的方法，以及通过抑制激酶或激酶途径治疗或预防的疾病，包括向需要的受试者施用有效量杂环芳基化合物。
• [EN] N-FORMYL HYDROXYLAMINE COMPOUNDS AS INHIBITORS OF PDF<br/>[FR] COMPOSES DE N-FORMYLE HYDROXYLAMINE EN TANT QU'INHIBITEURS DE PEPTIDYLE DEFORMYLASE (PDF)
  申请人：VERSICOR INC

  公开号：WO2002102790A1

  公开（公告）日：2002-12-27

  n-[01-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylamino-aryl or heteroaryl)- azacyclo 4-7 alkanes or thiazacyclo 4-7 alkanes or imidazacyclo 4-7 alkanes have interesting properties, e.g. in the treatment or prevention of disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections.

  n-[01-oxo-2-alkyl-3-(N-羟基甲酰胺基)-丙基]-(羰基氨基-芳基或杂环芳基)-氮杂环4-7烷或硫杂环4-7烷或咪唑氮杂环4-7烷具有有趣的性质，例如在治疗或预防能够通过肽脱甲基酶抑制剂治疗的疾病方面具有应用，如治疗细菌感染。