Propionsaeure-dichlormethylester | 13189-40-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Propionsaeure-dichlormethylester
• 英文别名: Dichloromethyl propanoate；dichloromethyl propanoate
• CAS: 13189-40-7
• 化学式: C₄H₆Cl₂O₂
• 分子量: 156.996
• InChiKey: WAQURDWQVPZKGT-UHFFFAOYSA-N

物化性质

• 沸点：
  126.6±20.0 °C(Predicted)
• 密度：
  1.295±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (溴-二氯甲基)-苯基汞 、 丙酸 以 苯 为溶剂， 生成 Propionsaeure-dichlormethylester
  参考文献：
  名称：

  Halomethyl-Metal Compounds. VII. The Reaction of Phenyl(bromodichloromethyl)mercury with Carboxylic Acids²

  摘要：

  DOI：

  10.1021/ja00972a028

文献信息

• Tylosin derivatives
  申请人：SANRAKU-OCEAN CO., LTD.

  公开号：EP0001841A2

  公开（公告）日：1979-05-16

  A number of 4"-acyl derivatives of tylosin and acetyltylosin which are prepared by first protectively acylating at the 2'-hydroxyl group of tylosin or acetyitylosin, secondly at the 4'''-hydroxyl group thereof, thirdly at the 4"-hydroxyl group thereof and finally deacylating the 2'- and 4'''-acyl groups to produce new 4" acyl derivatives of tylosin or scetyltylosin which effect high blood level compared to those tylosin derivatives heretofore are disclosed.

  本发明公开了一些泰乐菌素和乙酰基酪氨霉素的 4"-酰基衍生物，其制备方法是首先在泰乐菌素或乙酰基酪氨霉素的 2'-羟基上进行保护性酰化，其次在其 4''-羟基上进行保护性酰化，第三在其 4"-羟基上进行保护性酰化，最后在 2'-和 4''-酰基上进行脱酰化，从而制备出新的泰乐菌素或乙酰基酪氨霉素的 4"-酰基衍生物，与迄今为止的泰乐菌素衍生物相比，这些衍生物具有较高的血药浓度。
• Folli, Ugo; Goldoni, Francesca; Iarossi, Dario, Journal of the Chemical Society. Perkin transactions II, 1995, # 5, p. 1017 - 1020
  作者：Folli, Ugo、Goldoni, Francesca、Iarossi, Dario、Sbardellati, Silvia、Taddei, Ferdinando

  DOI：——

  日期：——
• PHOTO-RADICAL CURE OF SILICONES
  申请人：3M Innovative Properties Company

  公开号：EP3688098A1

  公开（公告）日：2020-08-05
• [EN] PHOTO-RADICAL CURE OF SILICONES<br/>[FR] DURCISSEMENT PHOTO-RADICALAIRE DE SILICONES
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2019064116A1

  公开（公告）日：2019-04-04

  Silicone-based elastomeric materials, articles containing the silicone-based elastomeric materials, reaction mixtures used to form the silicone-based elastomeric materials, and methods of making the silicone-based elastomeric materials are described. The silicone-based elastomeric materials are prepared by polymerizing silicone compounds having at least two ethylenically unsaturated groups in the presence of actinic radiation and a controlled radical initiator. The controlled radical initiators are bis-dithiocarbamate or bis-dithiocarbonate compounds having a single carbon between the two dithiocarbamate or dithiocarbonate groups. The silicone-based elastomeric materials typically have improved mechanical properties compared to silicone-based elastomeric materials formed by free radical polymerization reactions in the presence of conventional photoinitiators.