1,1,1-trifluoro-4-(1H-indol-3-yl)but-3-en-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1,1,1-trifluoro-4-(1H-indol-3-yl)but-3-en-2-one
• 化学式: C₁₂H₈F₃NO
• mdl: MFCD00209620
• 分子量: 239.19
• InChiKey: NVKOBNNCHGLNGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Pyrazoline derivatives useful for the treatment of cancer
  申请人：Cuberes Altisen Rosa

  公开号：US20070066651A1

  公开（公告）日：2007-03-22

  Compounds of formula (I) wherein: X is selected from the group consisting of trihalomethyl, C 1 -C 6 alkyl, and a group of formula (II) wherein: R 3 and R 4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C 1 -C 6 alkyl; C 1 -C 6 alkoxy; carboxy; C 1 -C 6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.

  化合物的公式（I），其中： X被选自三卤甲基，C1-C6烷基和公式（II）中的一组，其中： R3和R4分别被选自氢，卤素，羟基，硝基，C1-C6烷基，C1-C6烷氧基，羧基，C1-C6三卤代烷基和氰基的一组； Z被选自取代和未取代芳基；或其药学上可接受的盐。这些化合物是环氧合酶-2活性的抑制剂。它们可用于治疗环氧合酶介导的疾病，包括例如炎症，肿瘤性疾病和血管生成介导的疾病。
• Polymeric antireflective coatings deposited by plasma enhanced chemical vapor deposition
  申请人：BREWER SCIENCE, INC.

  公开号：US20030054117A1

  公开（公告）日：2003-03-20

  An improved method for applying polymeric antireflective coatings to substrate surfaces and the resulting precursor structures are provided. Broadly, the methods comprise plasma enhanced chemical vapor depositing (PECVD) a polymer on the substrate surfaces. The most preferred starting monomers are 4-fluorostyrene, 2,3,4,5,6-pentafluorostyrene, and allylpentafluorobenzene. The PECVD processes comprise subjecting the monomers to sufficient electric current and pressure so as to cause the monomers to sublime to form a vapor which is then changed to the plasma state by application of an electric current. The vaporized monomers are subsequently polymerized onto a substrate surface in a deposition chamber. The inventive methods are useful for providing highly conformal antireflective coatings on large surface substrates having super submicron (0.25 &mgr;m or smaller) features. The process provides a much faster deposition rate than conventional chemical vapor deposition (CVD) methods, is environmentally friendly, and is economical.

  本发明提供了一种改进的方法，可将聚合物抗反射涂层应用于基底表面及由此产生的前驱体结构。概括地说，该方法包括在基底表面进行等离子体增强化学气相沉积（PECVD）聚合物。最优选的起始单体是 4-氟苯乙烯、2,3,4,5,6-五氟苯乙烯和烯丙基五氟苯。PECVD 工艺包括将单体置于足够的电流和压力下，使单体升华形成蒸汽，然后通过施加电流将蒸汽转变为等离子状态。气化的单体随后在沉积室中聚合到基底表面上。本发明的方法适用于在具有超亚微米（0.25 微米或更小）特征的大表面基底上提供高保形防反射涂层。与传统的化学气相沉积（CVD）方法相比，该工艺的沉积速率快得多，而且环保、经济。
• 1-(4-SULFAMYLPHENYL)-3-TRIFLUOROMETHYL-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2
  申请人：Temple University of the Commonwealth System of Higher Education

  公开号：EP1191931B1

  公开（公告）日：2007-05-09
• EP1397260A4
  申请人：——

  公开号：EP1397260A4

  公开（公告）日：2006-03-08
• POLYMERIC ANTIREFLECTIVE COATINGS DEPOSITED BY PLASMA ENHANCED CHEMICAL VAPOR DEPOSITION
  申请人：Brewer Science, Inc.

  公开号：EP1397260A1

  公开（公告）日：2004-03-17