4-(4-(1H-pyrrol-1-yl)phenyl)butyl benzoate | 1137726-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-(4-(1H-pyrrol-1-yl)phenyl)butyl benzoate
• 英文别名: 4-(4-Pyrrol-1-ylphenyl)butyl benzoate
• CAS: 1137726-13-6
• 化学式: C₂₁H₂₁NO₂
• 分子量: 319.403
• InChiKey: GGCYBCYFMBAUBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  potassium 4-benzoyloxybutyl trifluoroborate 、 1-(4-氯苯基)吡咯 在 palladium diacetate 、 potassium carbonate 、 2-二环己基磷-2',6'-二异丙氧基-1,1'-联苯 作用下， 以 水 、 甲苯 为溶剂， 反应 24.0h， 以94%的产率得到4-(4-(1H-pyrrol-1-yl)phenyl)butyl benzoate
  参考文献：
  名称：

  Suzuki−Miyaura Cross-Coupling Reactions of Primary Alkyltrifluoroborates with Aryl Chlorides

  摘要：

  Parallel microscale experimentation was used to develop general conditions for the Suzuki-Miyaura cross-coupling of diversely functionalized primary alkyltrifluoroborates with a variety of aryl chlorides. These conditions were found to be amenable to coupling with aryl bromides, iodides, and triflates as well. The conditions that were previously identified through similar techniques to promote the cross-coupling of secondary alkyltrifluoroborates with aryl chlorides were not optimal for the primary alkyltrifluoroborates, thus demonstrating the value of parallel experimentation to develop novel, substrate specific results.

  DOI：

  10.1021/jo900152n

文献信息

• Suzuki−Miyaura Cross-Coupling Reactions of Primary Alkyltrifluoroborates with Aryl Chlorides
  作者：Spencer D. Dreher、Siang-Ee Lim、Deidre L. Sandrock、Gary A. Molander

  DOI：10.1021/jo900152n

  日期：2009.5.15

  Parallel microscale experimentation was used to develop general conditions for the Suzuki-Miyaura cross-coupling of diversely functionalized primary alkyltrifluoroborates with a variety of aryl chlorides. These conditions were found to be amenable to coupling with aryl bromides, iodides, and triflates as well. The conditions that were previously identified through similar techniques to promote the cross-coupling of secondary alkyltrifluoroborates with aryl chlorides were not optimal for the primary alkyltrifluoroborates, thus demonstrating the value of parallel experimentation to develop novel, substrate specific results.