2-amino-N-(3-piperidin-1-ylpropyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-N-(3-piperidin-1-ylpropyl)benzamide
• 化学式: C₁₅H₂₃N₃O
• 分子量: 261.36
• InChiKey: YMQPRKLPQDMEAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• 3-Aminoindazole derivatives and process for preparation thereof
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0049779A1

  公开（公告）日：1982-04-21

  A compound of the formula (I): wherein W, is a hydrogen atom or a group wherein Y is a C1-6 alkylene group or a C1-6 alkylene group having a C1-6 alkyl group substituent; and R, and R2 each independently is a hydrogen atom or a C1-6 alkyl group and R,, R2 and the adjacent nitrogen atom may form a C4-6 heterocyclic ring or a C4-6 heterocyclic ring containing an additional nitrogen atom and the C4-6 heterocyclic rings may have at least one C1-6 alkyl group, hydroxyl group or halogen atom; W2 is a hydrogen atom or a group wherein Z is a C1-6 alkylene group or a C1-6 alkylene group having a C1-6 alkyl group substituent; and R3 and R4 each independently is a hydrogen atom or a C1-6 alkyl group and R3, R4 and the adjacent nitrogen atom may form a C4-6 hetercyclic ring or a C4-6 heterocyclic ring containing an additional nitrogen atom and the C4-6 heterocyclic rings may have at least one C1-6 alkyl group, hydroxyl group or halogen atom; when W, is a hydrogen atom, W2 is the group; and when W2 is a hydrogen atom, W, is the group; and the pharmaceutically acceptable acid addition salt thereof.

  式 (I) 的化合物： 其中 W，是氢原子或 其中 Y 是 C1-6 亚烷基或具有 C1-6 烷基取代基的 C1-6 亚烷基；R 和 R2 各自独立地是氢原子或 C1-6 烷基，且 R、R2 和相邻的氮原子可形成 C4-6 杂环或含有额外氮原子的 C4-6 杂环，且 C4-6 杂环可具有至少一个 C1-6 烷基、羟基或卤素原子； W2 是氢原子或 其中 Z 为 C1-6 亚烷基或具有 C1-6 烷基取代基的 C1-6 亚烷基；以及 R3 和 R4 各自独立地为氢原子或 C1-6 烷基，且 R3、R4 和相邻氮原子可形成 C4-6 杂环或含有额外氮原子的 C4-6 杂环，且 C4-6 杂环可具有至少一个 C1-6 烷基、羟基或卤素原子； 当 W 是氢原子时，W2 是 基团；以及 当 W2 是氢原子时，W, 是基团；及 基团；及其药学上可接受的酸加成盐。
• [EN] ARYL COMPOUNDS, THEIR PREPARATION AND THEIR USE IN THERAPY<br/>[FR] COMPOSES ARYLE, LEUR ELABORATION ET LEUR UTILISATION EN THERAPIE,
  申请人：RIBOTARGETS LTD

  公开号：WO2002000614A1

  公开（公告）日：2002-01-03

  The present invention relates to compounds of the formula (I) wherein X is selected from O, S, SO, SO2, NR, CR2, C(OH)R and C=O; each R1 is independently selected from H, C¿1-12?alkyl and C3-12aryl; R?2¿ is selected from H, C¿1-12?alkyl and C3-12aryl; R?3¿ is selected C¿1-12?alkyl, C1-12alkoxy, C1-12alkanoyl, C3-12aryl, C3-12aryloxy and C3-12aryloyl; Y?1 and Y2¿ are independently selected from C¿1-12?alkylene, C4-12arylene, C4-16aralkylene, CO(C1-12alkylene), CO(C4-12arylene) and CO(C4-16aralkylene) groups; A and B are independently selected from groups comprising a group selected from: amine (-NR2), amide (-CONR2), amidine (-C(=NR)NR2), thioamide (-CSNR2), oxime (=NOR), hydroxylamine (-NHOR), hydroxamic acid (-CONROR), hydrazine (-NRNR2), hydrazone (=NNR2), sulphonamide (-SO2NR2), sulphinamide (-SONR2), sulphoximine (-SO(=NR)-), urea (-NRCONR2), guanidine (-NRC(=NR)NR2), and aromatic and non-aromatic nitrogen heterocylic groups; each R is independently selected fom H, C1-12alkyl or C3-12aryl, or any two R groups may together comprise a C1-6alkylene chain; or a pharmaceutically acceptable derivative thereof. The invention further relates to use of such compounds in the treatment of viral infection.