N-allyl-2-(8-allyloxyoctyloxy)acetamide | 881852-19-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-allyl-2-(8-allyloxyoctyloxy)acetamide
• 英文别名: 2-(8-prop-2-enoxyoctoxy)-N-prop-2-enylacetamide
• CAS: 881852-19-3
• 化学式: C₁₆H₂₉NO₃
• 分子量: 283.411
• InChiKey: ZELKLRQHJDQWNC-UHFFFAOYSA-N

物化性质

• 沸点：
  423.7±45.0 °C(Predicted)
• 密度：
  0.940±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-allyl-2-(8-allyloxyoctyloxy)acetamide 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 2,6-二叔丁基-4-甲基苯酚 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以58%的产率得到(E)-1,9-Dioxa-4-aza-cycloheptadec-6-en-3-one
  参考文献：
  名称：

  Using Cross-Metathesis to Couple l-Phenylalanine to a Macrocyclic Lactam

  摘要：

  Grubbs' second generation ruthenium catalyst was used to Couple the amino acid L-phenylalanine to a 17-membered lactam, using cross-metathesis with an E-alkene favored in the process. The best coupling conditions have the product in 48% yield. The reversibility of the process was also confirmed. Ring-closing metathesis was a key reaction used to form the macrocyclic lactam.

  DOI：

  10.1021/jo052415e
• 作为产物：
  描述：

  1,8-辛二醇 在 四丁基碘化铵 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 N-allyl-2-(8-allyloxyoctyloxy)acetamide
  参考文献：
  名称：

  Using Cross-Metathesis to Couple l-Phenylalanine to a Macrocyclic Lactam

  摘要：

  Grubbs' second generation ruthenium catalyst was used to Couple the amino acid L-phenylalanine to a 17-membered lactam, using cross-metathesis with an E-alkene favored in the process. The best coupling conditions have the product in 48% yield. The reversibility of the process was also confirmed. Ring-closing metathesis was a key reaction used to form the macrocyclic lactam.

  DOI：

  10.1021/jo052415e

文献信息

• Using Cross-Metathesis to Couple <scp>l</scp>-Phenylalanine to a Macrocyclic Lactam
  作者：Eric Enholm、Tammy Low

  DOI：10.1021/jo052415e

  日期：2006.3.1

  Grubbs' second generation ruthenium catalyst was used to Couple the amino acid L-phenylalanine to a 17-membered lactam, using cross-metathesis with an E-alkene favored in the process. The best coupling conditions have the product in 48% yield. The reversibility of the process was also confirmed. Ring-closing metathesis was a key reaction used to form the macrocyclic lactam.