Bz-Arg-Leu-NH2 | 66127-57-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bz-Arg-Leu-NH2
• 英文别名: Benzoylarginine leucinamide；N-[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]benzamide
• CAS: 66127-57-9
• 化学式: C₁₉H₃₀N₆O₃
• 分子量: 390.486
• InChiKey: WWMQJEYRSRMPQV-GJZGRUSLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  28
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  166
• 氢给体数：
  5
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  亮氨酰胺 、 N-alpha-苯甲酰基-L-精氨酸乙酯盐酸盐 在 4-morpholinepropanesulfonate buffer 、 methyltrypsin 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 4.0h， 以66%的产率得到Bz-Arg-Leu-NH2
  参考文献：
  名称：

  Methyltrypsin-Catalyzed Peptide Coupling: Comparison of Alkyl Ester and Guanidinophenyl Ester Derivatives as Acyl Donor Component

  摘要：

  Methyltrypsin-catalyzed peptide synthesis has been studied by using conventional alkyl ester and p-guanidinophenyl ester derivatives of alpha-amino acid as the acyl donor component. They were found to be coupled with alpha-amino acid derivatives (acyl acceptor component) to produce dipeptide. The behavior of methyltrypsin toward both the substrates has been studied. (C) 1997 Academic Press.

  DOI：

  10.1006/bioo.1997.1076

文献信息

• Synthesis, biological evaluation, and docking studies of PAR2-AP-derived pseudopeptides as inhibitors of kallikrein 5 and 6
  作者：Beatrice Severino、Ferdinando Fiorino、Angela Corvino、Giuseppe Caliendo、Vincenzo Santagada、Diego Magno Assis、Juliana R. Oliveira、Luiz Juliano、Serena Manganelli、Emilio Benfenati、Francesco Frecentese、Elisa Perissutti、Maria Aparecida Juliano

  DOI：10.1515/hsz-2014-0190

  日期：2015.1.1

  A series of protease activated receptor 2 activating peptide (PAR2-AP) derivatives (1–15) were designed and synthesized. The obtained compounds were tested on a panel of human kallikreins (hKLK1, hKLK2, hKLK5, hKLK6, and hKLK7) and were found completely inactive toward hKLK1, hKLK2, and hKLK7. Aiming to investigate the mode of interaction between the most interesting compounds and the selected hKLKs, docking studies were performed. The described compounds distinguish the different human tissue kallikreins with compounds 1 and 5 as the best hKLK5 and hKLK6 inhibitors, respectively.

  一系列蛋白酶激活受体2激活肽（PAR2-AP）衍生物（1-15）被设计并合成。获得的化合物在一系列人类激肽酶（hKLK1、hKLK2、hKLK5、hKLK6和hKLK7）上进行了测试，发现对hKLK1、hKLK2和hKLK7完全无活性。为了研究最有趣的化合物与选择的hKLKs之间的相互作用方式，进行了对接研究。所描述的化合物区分了不同的人类组织激肽酶，其中化合物1和5分别是最好的hKLK5和hKLK6抑制剂。
• Methyltrypsin-Catalyzed Peptide Coupling: Comparison of Alkyl Ester and Guanidinophenyl Ester Derivatives as Acyl Donor Component
  作者：Kunihiko Itoh、Haruo Sekizaki、Eiko Toyota、Kazutaka Tanizawa

  DOI：10.1006/bioo.1997.1076

  日期：1997.10

  Methyltrypsin-catalyzed peptide synthesis has been studied by using conventional alkyl ester and p-guanidinophenyl ester derivatives of alpha-amino acid as the acyl donor component. They were found to be coupled with alpha-amino acid derivatives (acyl acceptor component) to produce dipeptide. The behavior of methyltrypsin toward both the substrates has been studied. (C) 1997 Academic Press.