N-Hexanoylglycine sodium salt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Hexanoylglycine sodium salt
• 英文别名: Sodium;2-(hexanoylamino)acetate
• 化学式: C₈H₁₄NO₃*Na
• 分子量: 195.194
• InChiKey: KTIJBBFNDVAKRH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.56
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  69.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-Hexanoylglycine sodium salt 在 重水 作用下， 生成
  参考文献：
  名称：

  N-酰基甘氨酸单体盐和二聚体盐的振动光谱研究：长的酰基链对NH（ND）拉伸，酰胺I，酰胺II和CH 2-摆动模式的影响

  摘要：

  的振动光谱Ñ -acylglycine单体和二聚体的盐和它们的Ñ -deuteriated衍生物已经为了阐明长被研究Ñ酰基链的效果，这促进了聚甘氨酸II（PGII）样的结构Ñ -acylglycine低聚物（Ñ = 3-5）。结果总结如下。对于这些非常简单的低聚物，长的酰基链会引起NH拉伸模式的较大上移以及酰胺I和II模式的向下移动。对于单体盐而言，这种长的酰基链效应是明显的，表明它主要发生在与酰基末端相邻的肽键处。对于单体盐和二聚体盐，甘氨酸-CH的拉曼光谱图较长的酰基链促进了2种特征模式，它们类似于N-酰基甘氨酸低聚物的PGII样结构（ n = 3–5）和PGII的那些模式。

  DOI：

  10.1039/ft9949003483

文献信息

• High-absorbable transvaginal preparation containing biologically active peptides
  申请人：TEIKOKU SEIYAKU KABUSHIKI KAISHA

  公开号：EP0418642A1

  公开（公告）日：1991-03-27

  A high-absorbable transvaginal preparation having excellent absorbability of the active ingredient, which comprises a biologically active polypeptide and an absorption promoter comprising a polyoxyethylenealkylphenyl ether and one or more compounds selected from the group consisting of an N-acylamino acid, cholic acids, pectic acid, taurine, saccharin, glycyrrhizic acid, aspartame, or a salt thereof.

  一种高吸收性经阴道制剂，其活性成分具有极佳的可吸收性，该制剂由生物活性多肽和吸收促进剂组成，吸收促进剂包括聚氧乙烯烷基苯基醚和一种或多种选自 N-酰基氨基酸、胆酸、果胶酸、牛磺酸、糖精、甘草酸、阿斯巴甜或其盐类的化合物。
• AMADORIASE HAVING IMPROVED ANIONIC-SURFACTANT RESISTANCE
  申请人：Kikkoman Corporation

  公开号：EP3216865A1

  公开（公告）日：2017-09-13

  The present invention provides a composition that enables measurement of glycated hemoglobin in the presence of a stronger surfactant than conventional surfactants. To this end, the present invention provides an amadoriase in which one or more amino acids have been substituted at positions corresponding to positions selected from the group consisting of positions 80, 71, 175, 172, 279, 12, 9, 77, 30, 28, 13, 3, 4, 286, 204, 338, 44, 340, and 194 of the amadoriase derived from the genus Coniochaeta having the amino acid sequence as shown in SEQ ID NO: 1 as well as a composition for measurement of glycated hemoglobin comprising an amadoriase that retains activity in the presence of an anionic surfactant. The present invention can provide an enzyme and a composition for measurement of glycated hemoglobin that sufficiently remain stable even when exposed to anionic surfactants.

  本发明提供了一种组合物，该组合物能够在比传统表面活性剂更强的表面活性剂存在下测量糖化血红蛋白。为此，本发明提供了一种氨甲蝶呤酶，其中一个或多个氨基酸在与选自具有 SEQ ID NO：1 所示氨基酸序列的氨甲蝶呤酶，以及一种用于测量糖化血红蛋白的组合物，该组合物包含一种在阴离子表面活性剂存在下仍能保持活性的氨甲蝶呤酶。本发明可提供一种用于测量糖化血红蛋白的酶和组合物，即使暴露于阴离子表面活性剂中也能充分保持稳定。
• Amadoriase having enhanced anionic surfactant tolerance
  申请人：Kikkoman Corporation

  公开号：US11198852B2

  公开（公告）日：2021-12-14

  The present invention provides a composition that enables measurement of glycated hemoglobin in the presence of a stronger surfactant than conventional surfactants. To this end, the present invention provides an amadoriase in which one or more amino acids have been substituted at positions corresponding to positions selected from the group consisting of positions 80, 71, 175, 172, 279, 12, 9, 77, 30, 28, 13, 3, 4, 286, 204, 338, 44, 340, and 194 of the amadoriase derived from the genus Coniochaeta having the amino acid sequence as shown in SEQ ID NO: 1 as well as a composition for measurement of glycated hemoglobin comprising an amadoriase that retains activity in the presence of an anionic surfactant. The present invention can provide an enzyme and a composition for measurement of glycated hemoglobin that sufficiently remain stable even when exposed to anionic surfactants.

  本发明提供了一种组合物，该组合物能够在比传统表面活性剂更强的表面活性剂存在下测量糖化血红蛋白。为此，本发明提供了一种氨甲蝶呤酶，其中一个或多个氨基酸在与选自具有 SEQ ID NO：1 所示氨基酸序列的氨甲蝶呤酶，以及一种测量糖化血红蛋白的组合物，该组合物包含一种在阴离子表面活性剂存在下仍能保持活性的氨甲蝶呤酶。本发明可提供一种用于测量糖化血红蛋白的酶和组合物，即使暴露于阴离子表面活性剂中也能充分保持稳定。
• AMADORIASE HAVING ENHANCED ANIONIC-SURFACTANT TOLERANCE
  申请人：Kikkoman Corporation

  公开号：EP3216865B1

  公开（公告）日：2020-09-30
• AMADORIASE HAVING ENHANCED ANIONIC SURFACTANT TOLERANCE
  申请人：Kikkoman Corporation

  公开号：US20180237755A1

  公开（公告）日：2018-08-23

  The present invention provides a composition that enables measurement of glycated hemoglobin in the presence of a stronger surfactant than conventional surfactants. To this end, the present invention provides an amadoriase in which one or more amino acids have been substituted at positions corresponding to positions selected from the group consisting of positions 80, 71, 175, 172, 279, 12, 9, 77, 30, 28, 13, 3, 4, 286, 204, 338, 44, 340, and 194 of the amadoriase derived from the genus Coniochaeta having the amino acid sequence as shown in SEQ ID NO: 1 as well as a composition for measurement of glycated hemoglobin comprising an amadoriase that retains activity in the presence of an anionic surfactant. The present invention can provide an enzyme and a composition for measurement of glycated hemoglobin that sufficiently remain stable even when exposed to anionic surfactants.