4-ethyl-2-phenylfuran | 738623-32-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-ethyl-2-phenylfuran
• CAS: 738623-32-0
• 化学式: C₁₂H₁₂O
• 分子量: 172.227
• InChiKey: MNQNGBPXADRXCE-UHFFFAOYSA-N

物化性质

• 沸点：
  244.2±9.0 °C(Predicted)
• 密度：
  1.011±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-苯基-戊-1-炔-3-酮 在 三甲基碘化锍 、 potassium tert-butylate 、 四丁基碘化铵 、 对甲苯磺酸 、 sodium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 生成 4-ethyl-2-phenylfuran
  参考文献：
  名称：

  2,4-二取代呋喃和4,6-二芳基取代2,3-苯并-1,3a,6a-三氮杂戊烯的合成

  摘要：

  酰基乙炔1a-h与苯并三唑2的反应得到中间体3a-h。在碱存在下用三甲基碘化锍处理 3a-h 得到中间体环氧乙烷 4a-h 和 2,3-苯并-1,3a,6a-三氮杂戊烯 7d-g，这取决于取代基。粗品 4a-h 的酸催化重排得到 2,4-二取代呋喃 5a-h。

  DOI：

  10.3998/ark.5550190.0005.208

文献信息

• Cyclization of 2-Alkynylallyl Alcohols to Highly Substituted Furans by Gold(I)-Carbene Complexes
  作者：A. Stephen K. Hashmi、Tobias Häffner、Matthias Rudolph、Frank Rominger

  DOI：10.1002/ejoc.201001479

  日期：2011.2

  Various 2-alkynylallyl alcohols were synthesized by a generally applicable Sonogashira coupling protocol. Subsequent gold-catalyzed transformation was investigated. The use of AuI catalysts bearing carbene ligands, of either the N-heterocyclic carbene or nitrogen acyclic carbene type, delivered the desired products with low catalyst loadings and under very mild reaction conditions. A broad array of

  通过普遍适用的 Sonogashira 偶联方案合成了各种 2-炔基烯丙醇。研究了随后的金催化转化。使用带有卡宾配体的 AuI 催化剂，无论是 N-杂环卡宾还是氮无环卡宾类型，都能以低催化剂负载量和非常温和的反应条件提供所需的产物。测试了多种底物，包括烷基、烯基和芳基取代的炔烃，以及具有两个炔基部分的底物。结果证明该方法具有广泛的范围。仲烯丙醇也可以耐受，并且可以高产率分离得到的三取代呋喃。
• CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD
  申请人：Ebel Heiner

  公开号：US20120053164A1

  公开（公告）日：2012-03-01

  The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. Formula (I), wherein A is selected from among a single bond, ═CH—, —CH 2 —, —O—, —S—, and —NH—; wherein n is 1, 2 or 3; wherein Z is C or N, the other variables are as defined in the claims, as well as in form of their acid addition salts with pharmacologically acceptable acids.
• COMPOUNDS USEFUL AS ANTIVIRAL AGENTS, COMPOSITIONS, AND METHODS OF USE
  申请人：Wang Guoxin

  公开号：US20130090339A1

  公开（公告）日：2013-04-11

  Novel 3-N-cycloalkyl-5-substituted-2-thioxothiazolidin-4-one derivatives that are effective for use in treating viral infections are described. Also described are pharmaceutical compositions comprising the 3-N-cycloalkyl-5-substituted-2-thioxothiazolidin-4-one derivatives and methods for using the compounds or compositions.
• PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF CCR2 ANTAGONISTS
  申请人：EBEL Heiner

  公开号：US20140336374A1

  公开（公告）日：2014-11-13

  The present invention relates to a process for the production of novel antagonists for CCR2 (CC chemokine receptor 2) and intermediates thereof.
• US8835440B2
  申请人：——

  公开号：US8835440B2

  公开（公告）日：2014-09-16