phenylalanine phenethylamide | 857792-21-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: phenylalanine phenethylamide
• 英文别名: Phenylalanin-phenaethylamid；dl-Phenylalanin-β-phenaethylamid；2-amino-3-phenyl-N-(2-phenylethyl)propanamide
• CAS: 857792-21-3
• 化学式: C₁₇H₂₀N₂O
• 分子量: 268.359
• InChiKey: RVOCIPPBVIEIKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-苯乙胺 生成 phenylalanine phenethylamide
  参考文献：
  名称：

  v. Braun; Muench, Chemische Berichte, 1927, vol. 60, p. 357

  摘要：

  DOI：

文献信息

• COMBINATORIAL COMPOSITIONS AND METHODS OF TREATING HEMOGLOBINOPATHIES
  申请人：Children's Medical Center Corporation

  公开号：EP2766041A1

  公开（公告）日：2014-08-20
• US20140271657A1
  申请人：——

  公开号：US20140271657A1

  公开（公告）日：2014-09-18
• [EN] COMBINATORIAL COMPOSITIONS AND METHODS OF TREATING HEMOGLOBINOPATHIES<br/>[FR] COMPOSITIONS COMBINATOIRES ET MÉTHODES DE TRAITEMENT D'HÉMOGLOBINOPATHIES
  申请人：CHILDRENS MEDICAL CENTER

  公开号：WO2013055985A1

  公开（公告）日：2013-04-18

  Provided herein are compositions and methods for increasing fetal hemoglobin expression (HbF) for the treatment and/or amelioration of the symptoms of a hemoglobinpathy in a mammal. The compositions comprise a combination of one or more inhibitors of BCL11A expression or activity with epigenetic modifers, such as inhibitors of DNA methylation and/or one or more inhibitors of histone deacetylases.
• [EN] COMPOSITIONS COMPRISING 2'-DEOXYCYTIDINE ANALOGS AND USE THEREOF FOR THE TREATMENT OF SICKLE CELL DISEASE, THALASSEMIA, AND CANCERS<br/>[FR] COMPOSITIONS COMPRENANT DES ANALOGUES DE LA 2'-DÉSOXYCYTIDINE ET LEUR UTILISATION POUR LE TRAITEMENT DE LA DRÉPANOCYTOSE, DE LA THALASSÉMIE ET DE CANCERS
  申请人：ADIMABIO LLC

  公开号：WO2021211890A1

  公开（公告）日：2021-10-21

  In one aspect, the disclosure relates to pharmaceutical compositions comprising 2'-deoxycytidine analogs, oral and other dosage formulations containing the same, and methods of making the same. In another aspect, the disclosure relates to methods of treating hematological disorders and diseases associated with abnormal cell proliferation using the same. In a still further aspect, the disclosure relates to kits comprising 2'-deoxycytidine analogs useful for treating hematological disorders and diseases associated with abnormal cell proliferation. In still another aspect, the disclosure relates to methods for increasing fetal hemoglobin levels in a subject. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
• [EN] COMPOSITIONS COMPRISING GARDOS CHANNEL ANTAGONISTS AND THEIR USES<br/>[FR] COMPOSITIONS COMPRENANT DES ANTAGONISTES DU CANAL GARDOS ET LEURS UTILISATIONS
  申请人：ADIMABIO LLC

  公开号：WO2022015893A2

  公开（公告）日：2022-01-20

  In one aspect, the disclosure herein relates to pharmaceutical compositions formulated as an oral dosage form comprising a therapeutically effective amount of at least one substituted triphenylacetamide analog, e.g., 2,2-bis(4-fluorophenyl)-2-phenylacetamide, optionally a second therapeutic agent, and methods of making same. In another aspect, the disclosure relates to methods of treating hematological disorders, e.g., a disorder associated with a sickling blood disorder and/or a thalassemia, by administering the disclosed pharmaceutical compositions to a subject. In a still further aspect, the disclosure relates to kits comprising at least one substituted triphenylacetamide analog, e.g., 2,2-bis(4-fluorophenyl)-2-phenylacetamide, useful for treating hematological disorders and diseases associated with a sickling blood disorder and/or a thalassemia. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.