methyl 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: methyl 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylate
• 化学式: C₁₄H₁₄ClNO₂
• 分子量: 263.72
• InChiKey: BDJYSXMSWWLFRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  42.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PROCESSES FOR THE PREPARATION OF 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND OF ITS PRECURSORS<br/>[FR] PROCÉDÉS POUR LA PRÉPARATION DE 6-CHLORO-2,3,4,9-TÉTRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE ET DE SES PRÉCURSEURS
  申请人：SIENA BIOTECH SPA

  公开号：WO2013057258A1

  公开（公告）日：2013-04-25

  The invention relates to a novel process for the preparation of rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I) through the conversion of a 3-bromo-2-oxo-cyclohexanecarboxylic acid alkyl ester (I'-a) into 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid alkyl ester (I'-b), which in turn is processed to yield the final product (I).

  该发明涉及一种新型工艺，用于制备rac-6-氯-2,3,4,9-四氢-1H-咔唑-1-甲酰胺(I)，通过将3-溴-2-氧代环己烷羧酸烷基酯(I'-a)转化为6-氯-2,3,4,9-四氢-1H-咔唑-1-羧酸烷基酯(I'-b)，然后处理得到最终产物(I)。
• PROCESS FOR THE PREPARATION OF 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND INTERMEDIATES THEREOF
  申请人：SIENA BIOTECH S.P.A.

  公开号：US20140303382A1

  公开（公告）日：2014-10-09

  The invention relates to a novel process for the preparation of rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I) in pharmaceutically acceptable polymorphic form, through the conversion of a 3-bromo-2-oxo-cyclohexanecarboxylic acid alkyl ester into 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid alkyl ester, which in turn is processed to yield the final product.

  本发明涉及一种新的制备rac-6-氯-2,3,4,9-四氢-1H-咔唑-1-羧酰胺（I）的药用可接受多晶形式的方法，通过将3-溴-2-氧代环己烷羧酸烷基酯转化为6-氯-2,3,4,9-四氢-1H-咔唑-1-羧酸烷基酯，进而加工成最终产品。
• Process for the preparation of 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide and intermediates thereof
  申请人：AOP ORPHAN PHARMACEUTICALS AG

  公开号：US10329254B2

  公开（公告）日：2019-06-25

  The invention relates to a novel process for the preparation of rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I) in pharmaceutically acceptable polymorphic form, through the conversion of a 3-bromo-2-oxo-cyclohexanecarboxylic acid alkyl ester into 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid alkyl ester, which in turn is processed to yield the final product.

  本发明涉及一种新工艺，通过将 3-溴-2-氧代-环己烷羧酸烷基酯转化为 6-氯-2,3,4,9-四氢-1H-咔唑-1-羧酸烷基酯，制备药学上可接受的多晶型 rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I)。
• METHODS OF TREATING DISORDER
  申请人：Elixir Pharmaceuticals, Inc.

  公开号：EP1677794B1

  公开（公告）日：2014-12-03
• PROCESSES FOR THE PREPARATION OF 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND OF ITS PRECURSORS
  申请人：Siena Biotech S.p.A.

  公开号：EP2768807A1

  公开（公告）日：2014-08-27