N-acetyl-N'-propylpropylenediamine | 4189-54-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-N'-propylpropylenediamine
• 英文别名: N-[3-(propylamino)propyl]-acetamide；N-[3-(propylamino)propyl]acetamide
• CAS: 4189-54-2
• 化学式: C₈H₁₈N₂O
• 分子量: 158.244
• InChiKey: VAFXEUFLZONQSL-UHFFFAOYSA-N

物化性质

• 沸点：
  158-160 °C(Press: 15 Torr)
• 密度：
  0.9328 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-丙基-1,3-丙二胺 、 N-acetyl-N-(2-(trifluoromethyl)phenyl)acetamide 以 乙醇 为溶剂， 以89%的产率得到N-acetyl-N'-propylpropylenediamine
  参考文献：
  名称：

  The ortho-substituted N,N-diacetylaniline as a selective acetylating reagent

  摘要：

  Selective acetylation of the less hindered amino group in the presence of the more hindered amino group with the use of 2-trifluoromethyl-N,N-diacetylaniline 2c is described. This acetylation with 2c yielded the corresponding less hindered monoacetamide exclusively, simply, conveniently, and in good yields. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00745-4

文献信息

• Microwaves-assisted solvent-free synthesis of N-acetamides by amidation or aminolysis
  作者：Clotilde Ferroud、Marie Godart、Stéphane Ung、Hélène Borderies、Alain Guy

  DOI：10.1016/j.tetlet.2008.02.170

  日期：2008.4

  The preparation of acetamides directly from amines and an acetyl donor under microwaves without any catalyst is described. The inexpensive, solvent free, and fast reaction conditions are the important features of this procedure.

  描述了在微波下不用任何催化剂直接由胺和乙酰基供体制备乙酰胺的方法。廉价，无溶剂和快速的反应条件是该程序的重​​要特征。
• The ortho-substituted N,N-diacetylaniline as a selective acetylating reagent
  作者：Yasuoki Murakami、Kazuhiro Kondo、Kazuki Miki、Yoko Akiyama、Toshiko Watanabe、Yuusaku Yokoyama

  DOI：10.1016/s0040-4039(97)00745-4

  日期：1997.5

  Selective acetylation of the less hindered amino group in the presence of the more hindered amino group with the use of 2-trifluoromethyl-N,N-diacetylaniline 2c is described. This acetylation with 2c yielded the corresponding less hindered monoacetamide exclusively, simply, conveniently, and in good yields. (C) 1997 Elsevier Science Ltd.