Leu-Thr | 38062-82-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Leu-Thr
• 英文别名: L-leucyl-L-threonine；(2S,3R)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-hydroxybutanoic acid
• CAS: 38062-82-7
• 化学式: C₁₀H₂₀N₂O₄
• 分子量: 232.28
• InChiKey: LRKCBIUDWAXNEG-CSMHCCOUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Method for obtaining peptide fragments by use of fluorinated organic acids
  申请人：SEIKO INSTRUMENTS INC.

  公开号：EP0885899A1

  公开（公告）日：1998-12-23

  This method obtains peptide fragments having ends of specific amino acids from a protein, which does not use an enzyme and thus is associated with minimum contamination. An organic acid represented by a general formula; CF3-(CF2) n-COOH, wherein n is an integer of 0 or larger, is allowed to act on a protein or peptide.

  这种方法可以从蛋白质中获得具有特定氨基酸末端的肽片段，无需使用酶，因此污染最小。通式为 CF3-(CF2) n-COOH（其中 n 为 0 或更大的整数）的有机酸可作用于蛋白质或肽。
• PRECISE ESTIMATION OF GLOMERULAR FILTRATION RATE FROM MULTIPLE BIOMARKERS
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20170276669A1

  公开（公告）日：2017-09-28

  The present invention relates to the field of nephrology. More specifically, the present invention provides methods and compositions useful for more precisely estimating glomerular filtration rate (GFR). In a specific embodiment, a method for calculating the estimated glomerular filtration rate (eGFR) in a patient comprises the steps of (a) measuring the level of one or more metabolites using mass spectrometry from a blood sample obtained from the patient; and (b) calculating the eGFR using an algorithm that utilizes the measured levels of the one or more metabolites.