(2-Bromo-4-methyl-phenoxy)-acetyl chloride | 203571-86-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2-Bromo-4-methyl-phenoxy)-acetyl chloride
• 英文别名: (2-Bromo-4-methylphenoxy)-acetic acid chloride；2-(2-bromo-4-methylphenoxy)acetyl chloride
• CAS: 203571-86-2
• 化学式: C₉H₈BrClO₂
• 分子量: 263.518
• InChiKey: GAHTWFGUCIPIQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  、 (2-Bromo-4-methyl-phenoxy)-acetyl chloride 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 14.0h， 以34%的产率得到(3S,4R)-1-Allyl-3-(2-bromo-4-methyl-phenoxy)-4-((E)-1-methyl-2-phenyl-vinyl)-azetidin-2-one
  参考文献：
  名称：

  Heterocyclically bridged tricyclic β-lactames: A simple synthesis of 1,2,2a,8a-tetrahydro-3-oxa-1-aza-cyclobuta[b]naphthalen-2-ones

  摘要：

  The tricylic 3,4-bridged beta-lactames 7 and 8 containing a hetero atom as 3-substituent of the azetidin-2-one ring were synthesized by intramolecular radical cyclization using cis-substituted 3-(2-bromo-aryloxy)-azetidine-2-ones 6 as precursors. These precursors were generated by stereospecific acid chloride-imine reaction from the corresponding substituted (2-bromophenoxy)acetic acid chlorides 2 and imine 5.

  DOI：

  10.1007/bf00807565
• 作为产物：
  描述：

  2-溴-4-甲基苯酚 在 sodium hydroxide 、 氯化亚砜 作用下， 反应 3.0h， 生成 (2-Bromo-4-methyl-phenoxy)-acetyl chloride
  参考文献：
  名称：

  Heterocyclically bridged tricyclic β-lactames: A simple synthesis of 1,2,2a,8a-tetrahydro-3-oxa-1-aza-cyclobuta[b]naphthalen-2-ones

  摘要：

  The tricylic 3,4-bridged beta-lactames 7 and 8 containing a hetero atom as 3-substituent of the azetidin-2-one ring were synthesized by intramolecular radical cyclization using cis-substituted 3-(2-bromo-aryloxy)-azetidine-2-ones 6 as precursors. These precursors were generated by stereospecific acid chloride-imine reaction from the corresponding substituted (2-bromophenoxy)acetic acid chlorides 2 and imine 5.

  DOI：

  10.1007/bf00807565

文献信息

• Heterocyclically bridged tricyclic β-lactames: A simple synthesis of 1,2,2a,8a-tetrahydro-3-oxa-1-aza-cyclobuta[b]naphthalen-2-ones
  作者：A. Takó、K. -H. Ongania、K. Wurst

  DOI：10.1007/bf00807565

  日期：1997.11

  The tricylic 3,4-bridged beta-lactames 7 and 8 containing a hetero atom as 3-substituent of the azetidin-2-one ring were synthesized by intramolecular radical cyclization using cis-substituted 3-(2-bromo-aryloxy)-azetidine-2-ones 6 as precursors. These precursors were generated by stereospecific acid chloride-imine reaction from the corresponding substituted (2-bromophenoxy)acetic acid chlorides 2 and imine 5.