2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethan-1-amine | 872107-74-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethan-1-amine
• 英文别名: 2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethanamine
• CAS: 872107-74-9
• 化学式: C₁₄H₁₈N₂
• mdl: MFCD07686044
• 分子量: 214.31
• InChiKey: DWIMHBFTVNRUAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  31
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethan-1-amine 、 靛红 在 吡啶 、 三甲基氯硅烷 作用下， 反应 6.0h， 以71%的产率得到2',5',6',7'-tetrahydro-1',3'-dimethyl-2'-phenylspirophenylspiro[3Hindole-3,4'-[4H]pyrrolo[3,4-c]pyridin]-2(1H)-one
  参考文献：
  名称：

  Application of chlorotrimethylsilane in Pictet–Spengler reaction

  摘要：

  Chlorotrimethylsilane has been found to be an efficient condensing agent in the Pictet-Spengler reaction, affording an extremely straightforward synthetic route to tetrahydro-beta-carboline derivatives and their analogs. The applicability of the method has been studied, and a representative library of structurally diverse products has been created..

  DOI：

  10.1007/s00706-012-0804-7

文献信息

• Application of chlorotrimethylsilane in Pictet–Spengler reaction
  作者：Sergey V. Ryabukhin、Dmitriy M. Panov、Andrey S. Plaskon、Andrey A. Tolmachev、Radomyr V. Smaliy

  DOI：10.1007/s00706-012-0804-7

  日期：2012.11

  Chlorotrimethylsilane has been found to be an efficient condensing agent in the Pictet-Spengler reaction, affording an extremely straightforward synthetic route to tetrahydro-beta-carboline derivatives and their analogs. The applicability of the method has been studied, and a representative library of structurally diverse products has been created..