6-氟苯并(a)芘 | 59417-86-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 中文名称: 6-氟苯并(a)芘
• 英文名称: 6-fluorobenzopyrene
• 英文别名: 6-fluoro-benzo[a]pyrene；6-Fluorobenzopyren；6-Fluorobenzo(a)pyrene；6-fluorobenzo[a]pyrene
• CAS: 59417-86-6
• 化学式: C₂₀H₁₁F
• 分子量: 270.306
• InChiKey: WELROXOUKNZNRH-UHFFFAOYSA-N

物化性质

• 熔点：
  167-169 °C(Solv: acetone (67-64-1); methanol (67-56-1))
• 沸点：
  239.82°C (rough estimate)
• 密度：
  1.0872 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

SDS

反应信息

• 作为反应物：
  描述：

  6-氟苯并(a)芘 以 硫酸 为溶剂， 反应 10.0h， 生成 6-hydroxybenzopyrene
  参考文献：
  名称：

  EPR and ENDOR studies of 6-substituted benzo[a]pyrene cation radicals

  摘要：

  DOI：

  10.1021/ja00262a012
• 作为产物：
  描述：

  苯并[a]芘 在 N-fluoro-2,4-dinitroimidazole 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 72.0h， 以22%的产率得到6-氟苯并(a)芘
  参考文献：
  名称：

  Facile one-pot fluorination of polycyclic aromatic hydrocarbons (PAHs) with N-fluoro-2,4-dinitroimidazole; scope and limitation

  摘要：

  The synthetic utility of N-fluoro-2,4-dinitro-imidazole 'NF-2,4-DNI', a recently introduced NF fluorinating agent, has been tested for direct one-pot fluorination of several classes of polycyclic aromatic hydrocarbons, PAHs, namely pyrene, crowded alkyl(cycloalkyl)-pyrenes; hexahydro- and tetrahydro-pyrene; benzo[a] anthracene; benzo[a]- and benzo[e]pyrene; perylene; 2,7-di-tert-butylphenanthrene; chrysene; 9-methylanthracene and anthracene, as well as trans-15, 16-dimethyl-dihydropyrene; azuleno[1,2-a] acenaphthylene and azulene. Although the isolated yields are modest, the ease of handling of the reagent, simple operation (reflux in dichloroethane for 3 days) and the use of 1.1 equivalent of the reagent makes the procedure quite attractive for polynuclear aromatics, avoiding multi-step operations (NO2-PAH-->NH2-PAH-->N-2(+)-PAH-->F-PAH) or the use of toxic or costly reagents (CF3OF, XeF2, etc.); it provides direct one-pot access to a variety of F-PAHs that are not readily made using other fluorinating agents. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-1139(98)00224-3

文献信息

• Radical cations of benzo[α]pyrene and 6-substituted derivatives: reaction with nucleophiles and DNA
  作者：D. E. Stack、P. Cremonesi、A. Hanson、E. G. Rogan、E. L. Cavalieri

  DOI：10.3109/00498259509061890

  日期：1995.1

  1. Oxidation of benzo[a]pyrene (BP) by I2 in the presence of AgClO4 in benzene generates the BP.+ClO4-.AgI complex. This same method was used to produce radical cations from 6-FBP, 6-ClBP, 6-BrBP and 6-CH3BP. 2. Reaction of the BP, 6-FBP, 6-ClBP and 6-BrBP radical cation perchlorates with H2O produced BP 1,6-, 3,6- and 6,12- dione, whereas 6-CH3BP.+ClO4-.AgI yielded 6-CH2OHBP. 3. When BP.+ClO4-.AgI

  1.在AgClO4在苯中的存在下，I2氧化苯并[a] py（BP），生成BP。+ ClO4-.AgI复合物。使用相同的方法由6-FBP，6-ClBP，6-BrBP和6-CH3BP产生自由基阳离子。2.BP，6-FBP，6-ClBP和6-BrBP自由基阳离子高氯酸盐与H 2 O反应生成BP 1,6-，3,6-和6,12-二酮，而6-CH3BP。+ ClO4-。 AgI产生6-CH 2 OHBP。3.当BP。+ ClO4-.AgI和6-FBP。+ ClO4-.AgI与NaOAc在H2O / CH3CN（9：1）中反应时，除醌外，还形成了6-OAcBP。在6-ClBP。+ ClO4-.AgI的情况下，除了二酮以外，还形成少量的1-OAc-6-ClBP和3-OAc-6-ClBP，而对于6-BrBP和6-CH3BP反应产物分别为BP二酮和6-CH 2 OHBP。4.这些结果证实了电荷在BP。+中位于
• One-electron oxidation of 6-substituted benzo[a]pyrenes by manganic acetate. A model for metabolic activation
  作者：Paolo Cremonesi、Ercole L. Cavalieri、Eleanor G. Rogan

  DOI：10.1021/jo00276a013

  日期：1989.7
• Radical Cations of Benzo[a]pyrene and 6-Substituted Derivatives: Synthesis and Reaction with Nucleophiles
  作者：Paolo Cremonesi、Douglas E. Stack、Eleanor G. Rogan、Ercole L. Cavalieri

  DOI：10.1021/jo00104a024

  日期：1994.12

  Radical cations of benzo[a]pyrene (BP) and 6-substituted derivatives were synthesized by two methods: reaction of the hydrocarbon with I-2 and AgClO4 in benzene, and reaction of the hydrocarbon with NOBF4 in CH3CN/CH2Cl2. Both the radical cation perchlorates and tetrafluoroborates were stable for prolonged periods of time when stored under argon at subzero temperatures. The radical cations were reacted with nucleophiles of various strengths, namely H2O, AcO- and F-, as a means of best characterizing these intermediates, as well as determining their chemical properties. Reaction of BP, 6-FBP, 6-ClBP, and 6-BrBP radical cation perchlorates with H2O produced BP 1,6- 3,6-, and 6,12-dione, whereas the radical cation derived from 6-CH3BP yielded 6-CH2OHBP. When (BPClO4-)-Cl-.+ and 6-(FBPClO4-)-Cl-.+ were reacted with NaOAc in H2O/CH3CN (9:1), 6-OAcBP was formed, in addition to the quinones. 6-(ClBPClO4-)-Cl-.+ formed a small amount of 1-OAc-6-ClBP and 3-OAc-6-ClBP, in addition to the diones, whereas for 6-(BrBPClO4-)-Cl-.+ and 6-(CH3BPClO4-)-Cl-.+ the reaction products were BP diones and 6-CH2OHBP, respectively. Reactions conducted under anhydrous conditions, using tetramethylammonium acetate in CH3CN, gave similar results, except that no quinones were formed. These results confirm the reactivity of nucleophiles at the positions of high charge localization in the BP.+, i.e. C-6, followed by C-1 and C-3.
• CAVALIERI, ERCOLE L.;ROGAN, ELEANOR G.;CREMONESI, PAOLO;DEVANESAN, PRABHA+, BIOCHEM. PHARMACOL., 37,(1988) N 11, C. 2173-2182
  作者：CAVALIERI, ERCOLE L.、ROGAN, ELEANOR G.、CREMONESI, PAOLO、DEVANESAN, PRABHA+

  DOI：——

  日期：——
• Facile one-pot fluorination of polycyclic aromatic hydrocarbons (PAHs) with N-fluoro-2,4-dinitroimidazole; scope and limitation
  作者：Kenneth K. Laali、Mutsuo Tanaka、Farhad Forohar、Michael Cheng、John C. Fetzer

  DOI：10.1016/s0022-1139(98)00224-3

  日期：1998.9

  The synthetic utility of N-fluoro-2,4-dinitro-imidazole 'NF-2,4-DNI', a recently introduced NF fluorinating agent, has been tested for direct one-pot fluorination of several classes of polycyclic aromatic hydrocarbons, PAHs, namely pyrene, crowded alkyl(cycloalkyl)-pyrenes; hexahydro- and tetrahydro-pyrene; benzo[a] anthracene; benzo[a]- and benzo[e]pyrene; perylene; 2,7-di-tert-butylphenanthrene; chrysene; 9-methylanthracene and anthracene, as well as trans-15, 16-dimethyl-dihydropyrene; azuleno[1,2-a] acenaphthylene and azulene. Although the isolated yields are modest, the ease of handling of the reagent, simple operation (reflux in dichloroethane for 3 days) and the use of 1.1 equivalent of the reagent makes the procedure quite attractive for polynuclear aromatics, avoiding multi-step operations (NO2-PAH-->NH2-PAH-->N-2(+)-PAH-->F-PAH) or the use of toxic or costly reagents (CF3OF, XeF2, etc.); it provides direct one-pot access to a variety of F-PAHs that are not readily made using other fluorinating agents. (C) 1998 Elsevier Science S.A. All rights reserved.