1-[Azido-(2,3-dihydroindol-1-yl)-phenylmethyl]cyclobutane-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-[Azido-(2,3-dihydroindol-1-yl)-phenylmethyl]cyclobutane-1-carboxamide
• 英文别名: 1-[azido-(2,3-dihydroindol-1-yl)-phenylmethyl]cyclobutane-1-carboxamide
• 化学式: C20H21N5O
• 分子量: 347.4
• InChiKey: NPGQVDBKICIKSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  60.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• DERIVATIVES OF AMINOCYCLOBUTANE OR AMINOCYCLOBUTENE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICAL PRODUCTS
  申请人：Pierre Fabre Medicament

  公开号：EP2414323A1

  公开（公告）日：2012-02-08
• US8455550B2
  申请人：——

  公开号：US8455550B2

  公开（公告）日：2013-06-04
• [EN] DERIVATIVES OF AMINOCYCLOBUTANE OR AMINOCYCLOBUTENE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICAL PRODUCTS<br/>[FR] DÉRIVÉS D'AMINOCYCLOBUTANE OU D'AMINOCYCLOBUTÈNE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION COMME PRODUITS MÉDICAUX
  申请人：PF MEDICAMENT

  公开号：WO2010112597A1

  公开（公告）日：2010-10-07

  The present invention concerns compounds of general formula (1), where in : - -a-is a single or double bond, Ar is an aromatic group, substituted or unsubstituted, R1 and R2 each independently or together are: a hydrogen atom or C1-C6 alkyl group, branched or unbranched, saturated or unsaturated, substituted or unsubstituted; the groups R1 and R2 may also form a heterocycle, R3 and R3' each independently or together are a hydrogen atom or C1-C6 alkyl group, X is an oxygen atom or a sulphur atom, and the addition salts of the compounds of general formula (1) with pharmaceutically acceptable mineral acids or organic acids.