2,2-bis[2',2'-di(benzyloxymethyl)ethyoxymethyl]ethanol | 778592-64-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-bis[2',2'-di(benzyloxymethyl)ethyoxymethyl]ethanol
• 英文别名: 3-[3-Phenylmethoxy-2-(phenylmethoxymethyl)propoxy]-2-[[3-phenylmethoxy-2-(phenylmethoxymethyl)propoxy]methyl]propan-1-ol；3-[3-phenylmethoxy-2-(phenylmethoxymethyl)propoxy]-2-[[3-phenylmethoxy-2-(phenylmethoxymethyl)propoxy]methyl]propan-1-ol
• CAS: 778592-64-6
• 化学式: C₄₀H₅₀O₇
• 分子量: 642.833
• InChiKey: MWXXTKJAEULUAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  47
• 可旋转键数：
  25
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,2-bis[2',2'-di(benzyloxymethyl)ethyoxymethyl]ethanol 在 sodium azide 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 57.5h， 生成
  参考文献：
  名称：

  Convergent Synthesis of Dendrimers via the Passerini Three-Component Reaction

  摘要：

  Tuning properties by programming the surface functional group composition of surface-block dendrimers has been limited to dendrimers with only two types of surface functionality (i.e.., surface-diblock dendrimers). The Passerini reaction provides dendrimer products from precursor dendrons in reasonable yields. This proof-of-principle experiment opens the door to making surface-triblock dendrimers.

  DOI：

  10.1021/ol301263v
• 作为产物：
  描述：

  2-methylenepropane-1,3-bisbenzyl ether 在 15-冠醚-5 、 双氧水 、 sodium hydride 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 22.5h， 生成 2,2-bis[2',2'-di(benzyloxymethyl)ethyoxymethyl]ethanol
  参考文献：
  名称：

  Convergent Synthesis of Dendrimers via the Passerini Three-Component Reaction

  摘要：

  Tuning properties by programming the surface functional group composition of surface-block dendrimers has been limited to dendrimers with only two types of surface functionality (i.e.., surface-diblock dendrimers). The Passerini reaction provides dendrimer products from precursor dendrons in reasonable yields. This proof-of-principle experiment opens the door to making surface-triblock dendrimers.

  DOI：

  10.1021/ol301263v

文献信息

• Enhanced reactivity of dendrons in the Passerini three-component reaction
  作者：Jo-Ann Jee、Shuang Song、Jonathan G. Rudick

  DOI：10.1039/c4cc10091c

  日期：——

  Polymer chemistry has embraced multicomponent reactions for synthesizing multifunctional materials, including structurally perfect multimodal dendrimers. An unexpected substituent effect dramatically shortens the time required for the convergent synthesis of dendrimers via the Passerini three-component reaction.

  聚合物化学已经涵盖了用于合成多功能材料的多组分反应，包括结构完美的多峰树枝状大分子。出乎意料的取代基效应极大地缩短了通过Passerini三组分反应聚合合成树枝状聚合物所需的时间。
• Convergent Synthesis of Dendrimers via the Passerini Three-Component Reaction
  作者：Jo-Ann Jee、Lauren A. Spagnuolo、Jonathan G. Rudick

  DOI：10.1021/ol301263v

  日期：2012.7.6

  Tuning properties by programming the surface functional group composition of surface-block dendrimers has been limited to dendrimers with only two types of surface functionality (i.e.., surface-diblock dendrimers). The Passerini reaction provides dendrimer products from precursor dendrons in reasonable yields. This proof-of-principle experiment opens the door to making surface-triblock dendrimers.