5,5-dimethyl-N-[3-[2-[2-[3-[(2-methyl-3-oxobutan-2-yl)amino]propoxy]ethoxy]ethoxy]propyl]-4-oxohexanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5,5-dimethyl-N-[3-[2-[2-[3-[(2-methyl-3-oxobutan-2-yl)amino]propoxy]ethoxy]ethoxy]propyl]-4-oxohexanamide
• 化学式: C₂₃H₄₄N₂O₆
• 分子量: 444.6
• InChiKey: KRYCMOOQXNGLSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  31
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Compounds useful in the treatment and/or care of the skin, hair, nails, and/or mucous membranes
  申请人：LUBRIZOL ADVANCED MATERIALS, INC.

  公开号：US10799442B2

  公开（公告）日：2020-10-13

  Compounds of general formula (I): R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2 (I) their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, cosmetic and/or pharmaceutical compositions which contain them and their use in medicine, and in processes of treatment and/or care of the skin, hair and/or mucous membranes, in particular in the aging and photoaging of the skin.

  通式 (I) 的化合物：R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2（I）的立体异构体、它们的混合物和/或它们的化妆品或药剂上可接受的盐、含有它们的化妆品和/或药剂组合物，以及它们在医学、皮肤、头发和/或粘膜的治疗和/或护理过程中的用途，尤其是在皮肤老化和光老化方面的用途。
• COMPOUNDS USEFUL FOR THE TREATMENT AND/OR CARE OF THE SKIN, HAIR, NAILS AND/OR MUCOUS MEMBRANES
  申请人：LUBRIZOL ADVANCED MATERIALS, INC.

  公开号：US20200214960A1

  公开（公告）日：2020-07-09

  A compound of formula (I) R 1 -W m -X n -AA 1 -AA 2 -AA 3 -AA 4 -AA 5 -AA 6 -AA 7 -AA 8 -AA 9 -Y p -Z q -R 2 , wherein AA 1 is Phe; AA 2 is Trp; AA 3 is selected from Met, Leu and Ile; AA 4 is selected from Lys, Arg and Gln; AA 5 is Arg; AA 6 is Lys; AA 7 is selected from Arg, Lys and His; AA 8 is selected from Val, Ile, Leu and Met; and AA 9 is Pro. The compound is useful in the treatment and/or care of the skin, hair, nails and/or mucous membranes, in particular for improving the barrier function of the skin, for energizing the skin and as an anti-aging agent.