tert-Butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester | 473919-02-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-Butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester
• 英文别名: (4-Methoxyphenyl)methyl 2-[dimethoxy(oxido)phosphaniumyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate；(4-methoxyphenyl)methyl 2-[dimethoxy(oxido)phosphaniumyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
• CAS: 473919-02-7
• 化学式: C₁₇H₂₆NO₈P
• 分子量: 403.369
• InChiKey: WPQBVJJFIWKOTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  tert-Butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester 在 Rh((S,S)-DuPHOS) 氢气 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Diazonamide Synthesis Studies:  Use of Negishi Coupling to Fashion Diazonamide-Related Biaryls with Defined Axial Chirality

  摘要：

  [GRAPHICS]The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp(3) stereogenic center in a lactone tether in both cases.

  DOI：

  10.1021/ol026694t
• 作为产物：
  描述：

  N-BOC-(dimethylphosphono)glycine 、 4-甲氧基苄醇 在 N,N'-二环己基碳二亚胺 作用下， 以75%的产率得到tert-Butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester
  参考文献：
  名称：

  Diazonamide Synthesis Studies:  Use of Negishi Coupling to Fashion Diazonamide-Related Biaryls with Defined Axial Chirality

  摘要：

  [GRAPHICS]The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp(3) stereogenic center in a lactone tether in both cases.

  DOI：

  10.1021/ol026694t

文献信息

• Diazonamide Synthesis Studies:  Use of Negishi Coupling to Fashion Diazonamide-Related Biaryls with Defined Axial Chirality
  作者：Ken S. Feldman、Kyle J. Eastman、Guillaume Lessene

  DOI：10.1021/ol026694t

  日期：2002.10.1

  [GRAPHICS]The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp(3) stereogenic center in a lactone tether in both cases.