5-butyl-3-{[2-(morpholin-4-yl)ethyl]sulfanyl}-5H-[1,2,4]triazino[5,6-b]indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-butyl-3-{[2-(morpholin-4-yl)ethyl]sulfanyl}-5H-[1,2,4]triazino[5,6-b]indole
• 英文别名: 4-[2-[(5-butyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]ethyl]morpholine
• 化学式: C₁₉H₂₅N₅OS
• 分子量: 371.5
• InChiKey: GQHUNCMGIHZTTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• METHODS OF TREATING LEUKODYSTROPHIES
  申请人：Ramot at Tel-Aviv University Ltd.

  公开号：US20200061076A1

  公开（公告）日：2020-02-27

  Methods of treating leukodystrophy are provided. Accordingly there is provided a method of treating leukodystrophy in a subject, the method comprising administering to the subject a therapeutically effective amount of an agent capable of up-regulating activity and/or expression of a component participating in a Sigma-1 Receptor (Sig-1R) signaling pathway. Also provided are agents and methods of up-regulating activity of Sig-1R in a cell and treating a disease that can benefit from up-regulating activity of Sig-1R. Also provided are agents and methods of modulating activity of sonic hedgehog (SHH) in a cell and treating a disease that can benefit from modulating activity of SHH.