6-氨基己酰氯 | 66678-88-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 中文名称: 6-氨基己酰氯
• 英文名称: 6-Aminocaproylchlorid
• 英文别名: 6-amino-hexanoyl chloride；Hexanoyl chloride, 6-amino-；6-aminohexanoyl chloride
• CAS: 66678-88-4
• 化学式: C₆H₁₂ClNO
• mdl: MFCD11938900
• 分子量: 149.62
• InChiKey: ZAVDMSFCUCGSDM-UHFFFAOYSA-N

物化性质

• 沸点：
  204.6±23.0 °C(Predicted)
• 密度：
  1.070±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-氨基己酰氯 在 4-二甲氨基吡啶 、 碳酸氢钠 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 6-(3-bromo-2-bromomethylpropionylamino)hexanoic acid
  参考文献：
  名称：

  [EN] ANTIBODY-DRUG CONJUGATES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
  [FR] CONJUGUÉS DE MOLÉCULES BIOLOGIQUEMENT ACTIVES, RÉACTIFS ET MÉTHODES DE FABRICATION, ET UTILISATIONS THÉRAPEUTIQUES

  摘要：

  公开号：

  WO2015187596A3
• 作为产物：
  描述：

  6-氨基己酸 在 五氯化磷 、 乙酸酐 作用下， 生成 6-氨基己酰氯
  参考文献：
  名称：

  Rothe; Kunitz, Justus Liebigs Annalen der Chemie, 1957, vol. 609, p. 88,100

  摘要：

  DOI：

文献信息

• Transkarbams with terminal branching as transdermal permeation enhancers
  作者：Jana Klimentová、Petr Kosák、Kateřina Vávrová、Tomáš Holas、Jakub Novotný、Alexandr Hrabálek

  DOI：10.1016/j.bmcl.2008.01.040

  日期：2008.3

  Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, supporting the key role of the ammonium-carbamate polar head in the enhancing activity of T. (C) 2008 Elsevier Ltd. All rights reserved.
• Rothe et al., Journal fur praktische Chemie (Leipzig 1954), 1959, vol. <4> 8, p. 323,331
  作者：Rothe et al.

  DOI：——

  日期：——
• Interfacial polycondensation. VIII. Application to AB-type monomers
  作者：J. R. Schaefgen、F. H. Koontz、R. F. Tietz

  DOI：10.1002/pol.1959.1204013708

  日期：1959.11

  AbstractThe application of interfacial polycondensation to the preparation of several polyurethanes and polyamides from AB type monomers is described. The monomers are salts of aminoalkyl chloroformates and aminoacid chlorides, respectively. Differences in method and mechanism from the AA plus BB type interfacial polycondensation are discussed. Several new ring‐containing polymers were synthesized.
• Properties and structure–activity studies of cyclic β-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I
  作者：John A. Robinson、Sasalu C. Shankaramma、Peter Jetter、Ursula Kienzl、Reto A. Schwendener、Jan W. Vrijbloed、Daniel Obrecht

  DOI：10.1016/j.bmc.2005.01.009

  日期：2005.3

  The properties and structure-activity relationships (SAR) of a macrocyclic analogue of porcine protegrin I (PG-I) have been investigated. The lead compound, having the sequence cyclo-(-Leu-Arg-Leu-Lys-Lys-Arg-Arg-Trp-Lys-Tyr-Arg-Val-D-Pro-Pro-), shows antimicrobial activity against Gram-positive and -negative bacteria, but a much lower haemolytic activity and a much reduced ability to induce dye release from phosphatidylcholine/phosphatidylglycerol liposomes, when compared to PG-I. The enantiomeric form of the lead peptide shows comparable antimicrobial activity, a property shared with other cationic antimicrobial peptides acting on cell membranes. SAR studies involving the synthesis and biological profiling of over 100 single site substituted analogues, showed that the antimicrobial activity was tolerant to a large number of the substitutions tested. Some analogues showed slightly improved antimicrobial activities (2-4-fold lowering of MICs), whereas other substitutions caused large increases in haemolytic activity on human red blood cells. (c) 2005 Elsevier Ltd. All rights reserved.
• Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical composition, containing at least one of these compounds
  申请人：TEIJIN LIMITED

  公开号：EP0044541B1

  公开（公告）日：1983-09-21