5-(4-methoxy-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid hydroxyamide | 823220-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(4-methoxy-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid hydroxyamide
• 英文别名: N-Hydroxy-5-{[(4-methoxyphenyl)sulfanyl]methyl}-1,2-oxazole-3-carboxamide；N-hydroxy-5-[(4-methoxyphenyl)sulfanylmethyl]-1,2-oxazole-3-carboxamide
• CAS: 823220-07-1
• 化学式: C₁₂H₁₂N₂O₄S
• 分子量: 280.304
• InChiKey: KOCQFHZNTJFDJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-甲基-3-异噁唑羧酸乙酯 在 氢氧化钾 、 N-溴代丁二酰亚胺(NBS) 、 盐酸羟胺 、 potassium carbonate 、 过氧化苯甲酰 作用下， 以 甲醇 、 四氯化碳 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 5-(4-methoxy-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid hydroxyamide
  参考文献：
  名称：

  Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents

  摘要：

  A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.087

文献信息

• Isoxazoles as peptide deformylase inhibitors
  申请人：Cali Patrizia

  公开号：US20070043062A1

  公开（公告）日：2007-02-22

  Isoxazole compounds of formula (I) and pharmaceutically acceptable salts or esters thereof are peptide deformylase inhibitors useful in the treatment or prevention of infections and other disease in which peptide deformylases are involved, especially in the treatment of bacterial and parasitic infections, for example infections fully or partly caused by microorganisms belonging to Staphylococcus, Enterococcus, Streptococcus, Haemophilus, Moraxella, Escherichia, Mycobacterium, Mycoplasma, Pseudomonas, Chlamydia, Rickettsia, Klebsiella, Shigella, Salmonella, Bordetella, Clostridium, Helicobacter, Campylobacter, Legionella or Neisseria .
• Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents
  作者：Patrizia Calí、Lars Nærum、Seema Mukhija、Anders Hjelmencrantz

  DOI：10.1016/j.bmcl.2004.09.087

  日期：2004.12

  A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported. (C) 2004 Elsevier Ltd. All rights reserved.