3-methyl-3,4-dihydro-2H-dibenzo[b,e][1,4]diazepin-1-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 3-methyl-3,4-dihydro-2H-dibenzo[b,e][1,4]diazepin-1-ol
• 英文别名: 9-methyl-8,9,10,11-tetrahydrobenzo[b][1,4]benzodiazepin-7-one
• 化学式: C₁₄H₁₄N₂O
• 分子量: 226.27
• InChiKey: VRLDCDMBIUQHOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOUNDS FOR MODULATING TLR2
  申请人：Finberg Robert W.

  公开号：US20110152251A1

  公开（公告）日：2011-06-23

  The present invention is directed to methods, kits, and uses of inhibitors of LCMV mediated NF-κB activation to treat viral infections and inflammatory conditions.
• SMALL MOLECULE ANTI-SCARRING AGENTS
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20170216332A1

  公开（公告）日：2017-08-03

  Disclosed are methods of treating fibrosis in a patient in need thereof that includes administering to the patient an amount of an active agent, as identified herein, that is therapeutically effective to inhibit myofibroblast formation and thereby treat the fibrosis. Also disclosed is a recombinant cell line that includes a recombinant gene that expresses a detectable expression product in a dose-dependent response to TGFβ, as well as methods of identifying a compound that inhibits TGFβ-mediated expression of the detectable expression product.