N-(dipropyl-methyl)-morpholine | 121238-78-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-(dipropyl-methyl)-morpholine
• 英文别名: 4-Heptan-4-ylmorpholine
• CAS: 121238-78-6
• 化学式: C₁₁H₂₃NO
• 分子量: 185.31
• InChiKey: MFGUQVGPAIFEMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(3-hepten-4-yl)-morpholine 生成 N-(dipropyl-methyl)-morpholine 、 (3R,4R)-4-Morpholin-4-yl-heptan-3-ol
  参考文献：
  名称：

  硼烷的合成。3.通过硼氢化/氧化将对称的二烷基酮的吗啉和吡咯烷烯胺转化为相应的苏-β-氨基醇

  摘要：

  用BMS对对称二烷基酮的吗啉和吡咯烷烯胺进行氢硼化，然后进行甲醇分解和碱性过氧化氢氧化，以中等收率得到相应的苏-β-氨基醇。

  DOI：

  10.1016/s0040-4039(00)76877-8

文献信息

• TRISUBSTITUTED PYRIDO[2,3-D]PYRIMIDINES, METHODS FOR PREPARING SAME AND THERAPEUTIC USES THEREOF
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

  公开号：US20150203489A1

  公开（公告）日：2015-07-23

  The present invention relates to compounds of the following general formula (I): wherein: R 1 is notably a group —NR a R b , R a and R b forming together with the nitrogen atom onto which they are bound, a heterocycle comprising from 5 to 30 atoms, R 2 is notably an aryl comprising from 5 to 30 atoms, and R 3 is notably an alkenyl comprising from 1 to 20 carbon atoms.

  本发明涉及以下通式(I)的化合物： 其中： R1特别地是一个基团—NRaRb，Ra和Rb与它们所连接的氮原子一起形成一个包含5至30个原子的杂环； R2特别地是一个包含5至30个原子的芳基； R3特别地是一个包含1至20个碳原子的烯基。
• Trisubstituted pyrido[2,3-D]pyrimidines, methods for preparing same and therapeutic uses thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

  公开号：US10202372B2

  公开（公告）日：2019-02-12

  The present invention relates to compounds of the following general formula (I): wherein: R1 is notably a group —NRaRb, Ra and Rb forming together with the nitrogen atom onto which they are bound, a heterocycle comprising from 5 to 30 atoms, R2 is notably an aryl comprising from 5 to 30 atoms, and R3 is notably an alkenyl comprising from 1 to 20 carbon atoms.

  本发明涉及以下一般式（I）的化合物：其中：R1 明显是一个基团—NRaRb，Ra 和 Rb 与它们结合的氮原子一起形成一个含有 5 到 30 个原子的杂环，R2 明显是一个含有 5 到 30 个原子的芳基，R3 明显是一个含有 1 到 20 个碳原子的烯基。
• METHOD FOR PRODUCING CARBONYL COMPOUND AND FLOW REACTION SYSTEM USED FOR PRODUCTION OF CARBONYL COMPOUND
  申请人：FUJIFILM Corporation

  公开号：EP4019493A1

  公开（公告）日：2022-06-29

  There are provided a method of producing a carbonyl compound by a flow type reaction, including introducing a triphosgene solution into a flow channel (I), bringing the triphosgene solution into contact with a solid catalyst immobilized in at least a part of the flow channel (I) to generate a phosgene solution while the triphosgene solution is flowing through the flow channel (I), joining the phosgene solution and an active hydrogen-containing compound solution that flows inside the flow channel (II), which are subsequently allowed to flow downstream inside a reaction flow channel to be reacted in a presence of a tertiary amine, and obtaining a carbonyl compound in a joining solution; and a flow type reaction system that is suitable for carrying out this production method.

  提供了一种通过流动型反应生产羰基化合物的方法，包括将三光气溶液引入流动通道（I），在三光气溶液流经流动通道（I）时，使三光气溶液与固定在流动通道（I）至少一部分中的固体催化剂接触，生成光气溶液、将光气溶液与流道 (II) 内的活性含氢化合物溶液汇合，然后让它们顺流进入反应流道，在叔胺存在下进行反应，并在汇合溶液中获得羰基化合物；以及适用于该生产方法的流动式反应系统。
• Katritzky, Alan R.; Yannakopoulou, Konstantina; Lue, Ping, Journal of the Chemical Society. Perkin transactions I, 1989, p. 225 - 233
  作者：Katritzky, Alan R.、Yannakopoulou, Konstantina、Lue, Ping、Rasala, Danuta、Urogdi, Laszlo

  DOI：——

  日期：——
• PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS
  申请人：ARIAD PHARMACEUTICALS, INC.

  公开号：EP2300013B1

  公开（公告）日：2017-09-06