2-(4-Carbamimidoyl-phenyl)-1H-indole-5-carboxamidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(4-Carbamimidoyl-phenyl)-1H-indole-5-carboxamidine
• 英文别名: 2-(4-carbamimidoylphenyl)-1H-indole-5-carboximidamide
• 化学式: C₁₆H₁₅N₅
• 分子量: 277.329
• InChiKey: JUOBNLRIOAUTBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  116
• 氢给体数：
  5
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 氨 作用下， 以 乙醇 为溶剂， 生成 2-(4-Carbamimidoyl-phenyl)-1H-indole-5-carboxamidine
  参考文献：
  名称：

  Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)

  摘要：

  A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.06.021

文献信息

• Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement
  申请人：Lu Helen H.

  公开号：US10265155B2

  公开（公告）日：2019-04-23

  An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.

  本发明提供了一种用于软组织或软组织对骨修复、固定、增强或置换的可植入装置，该装置包括仿生物和可生物降解纳米纤维支架。此外，还提供了一种全合成可植入多阶段支架，它在单个连续结构中包括多个阶段，以模拟肌腱或韧带的自然解剖结构及其插入部位。还提供了用于肌肉骨骼组织工程的支架装置。
• BIOMIMMETIC NANOFIBER SCAFFOLD FOR SOFT TISSUE AND SOFT TISSUE-TO-BONE REPAIR, AUGMENTATION AND REPLACEMENT
  申请人：Lu Helen H.

  公开号：US20150100121A1

  公开（公告）日：2015-04-09

  An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.
• US5204352A
  申请人：——

  公开号：US5204352A

  公开（公告）日：1993-04-20
• US6329412B1
  申请人：——

  公开号：US6329412B1

  公开（公告）日：2001-12-11
• US9267948B2
  申请人：——

  公开号：US9267948B2

  公开（公告）日：2016-02-23