6-氯-2-甲硫基-1H-苯并咪唑 | 7692-57-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 6-氯-2-甲硫基-1H-苯并咪唑
• 英文名称: 5-chloro-2-(methylthio)-1H-benzimidazole
• 英文别名: 2-Mercaptomethyl-5-chlor-benzimidazol；5-chloro-2-methylsulfanyl-1(3)H-benzoimidazole；5-chloro-2-methylsulfanyl-1(3)H-benzimidazole；5-Chlor-2-methylmercapto-1(3)H-benzimidazol；6-chloro-2-methylsulfanyl-1H-benzimidazole
• CAS: 7692-57-1
• 化学式: C₈H₇ClN₂S
• mdl: MFCD08234601
• 分子量: 198.676
• InChiKey: ZYJPSJQXODTXBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  54
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  6-氯-2-甲硫基-1H-苯并咪唑 在 sodium thiosulfate 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 6-chloro-2-(methylsulfonyl)-1H-benzimidazole
  参考文献：
  名称：

  Anti-ischemic 2,4-diaminoquinazolines

  摘要：

  这项发明涉及特定的2,4-二氨基喹唑啉化合物，它们的药用盐，包含这些化合物的药物组合物以及它们的治疗用途方法。这些化合物具有抗缺血活性。

  公开号：

  US05576322A1
• 作为产物：
  描述：

  4-氯-1,2-苯二胺 在 氢氧化钾 作用下， 以 乙醇 、 水 为溶剂， 反应 3.0h， 生成 6-氯-2-甲硫基-1H-苯并咪唑
  参考文献：
  名称：

  Synthesis and antiparasitic activity of 1H-benzimidazole derivatives

  摘要：

  Compounds 1-18 have been synthesized and tested in vitro against the protozoa Giardia lamblia, Entamoeba histolytica and the helminth Trichinella spiralis. Inhibition of rat brain tubulin polymerization was also measured and compared for each compound. Results indicate that most of the compounds tested were more active as antiprotozoal agents than Metromdazole and Albendazole. None of the compounds was as active as Albendazole against T. spiralis. Although only compounds 3, 9 and 15 (2-methoxycarbonylamino derivatives) inhibited tubulin polymerization, these were not the most potent antiparasitic compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00346-3

文献信息

• [EN] NOVEL 2-SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF<br/>[FR] NOUVEAU COMPOSÉ IMIDAZOLE 2-SUBSTITUÉ ET SON UTILISATION
  申请人：OAT & IIL INDIA LAB PRIVATE LTD

  公开号：WO2016063293A1

  公开（公告）日：2016-04-28

  An object of the present invention is to provide novel 2-substituted imidazole compounds or salts thereof that have pesticidal activity. The present invention provides a 2-substituted imidazole compounds represented by Formula (1) : or a salt thereof, wherein R1, R2, and R3are identical or different and each represent hydrogen, or C1-C4-haloalkyl; R4represents (1) hydrogen or a substituent as defined herein, R5represents C1-12alkyl or other substituents as defined herein, A represents NR6, O or S(O)m, m = 0, 1 or 2, W, X, Y, and Z are identical or different and each represent CR4or N, R6 is C1-12 alkyl or a substituent as defined herein, and n is an integer of 1 to 4.

  本发明的目的是提供具有杀虫活性的新型2-取代咪唑化合物或其盐。本发明提供了由式（1）表示的2-取代咪唑化合物或其盐，其中R1，R2和R3相同或不同，分别表示氢或C1-C4卤代烷基；R4表示（1）氢或如下所定义的取代基，R5表示C1-12烷基或其他如下所定义的取代基，A表示NR6，O或S（O）m，m = 0，1或2，W，X，Y和Z相同或不同，分别表示CR4或N，R6表示C1-12烷基或如下所定义的取代基，n为1到4的整数。
• Benzimidazoles for ischemic heart conditions
  申请人：Eisai Co., Ltd.

  公开号：US05693652A1

  公开（公告）日：1997-12-02

  The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: ##STR1## \x9bin formula (1), ring A represents a benzene ring, a pyridine ring or a cyclohexane ring: ring B represents a pyridine ring, a pyrimidine ring or an imidazole ring, R.sup.1, R.sup.2, R.sup.3 R.sup.4, R.sup.5 and R.sup.6 are described herein.

  本发明提供了一种由下列通式（1）表示的含氮杂环化合物或其药学上可接受的盐，其对于各种缺血性心脏疾病等具有有用的作用：##STR1## 在式（1）中，环A表示苯环、吡啶环或环己烷环；环B表示吡啶环、嘧啶环或咪唑环；R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5和R.sup.6在此已描述。
• Quinazoline derivatives
  申请人：Eisai Co., Ltd.

  公开号：US05801180A1

  公开（公告）日：1998-09-01

  The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: ##STR1## \x9bin formula (1), ring A represents a benzene ring, a pyridine ring or a cyclohexane ring; ring B represents a pyridine ring, a pyrimidine ring or an imidazole ring, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent each a hydrogen atom, a halogen atom or a group such as a lower alkoxy group; R.sup.5 represents a group represented by the formula --NR.sup.11 R.sup.12 (wherein R.sup.11 and R.sup.12 represent each a hydrogen atom or a group such as a lower alkyl group) or the like; and R.sup.6 represents a group represented by the formula ##STR2## (wherein R.sup.19 represents a hydrogen atom, a lower alkyl group or the like; R.sup.20, R.sup.21 and R.sup.22 represent each a hydrogen atom, a halogen atom, a hydroxyl group or the like; and r represents 0 or an integer of 1 to 8)!.

  本发明提供了一种由以下通式（1）表示的含氮杂环化合物或其药学上可接受的盐，该化合物对各种缺血性心脏疾病等具有有用作用： ##STR1## 在公式（1）中，环A代表苯环、吡啶环或环己烷环；环B代表吡啶环、嘧啶环或咪唑环，R.sup.1、R.sup.2、R.sup.3和R.sup.4分别代表氢原子、卤原子或类似的低烷氧基团；R.sup.5代表由公式--NR.sup.11 R.sup.12（其中R.sup.11和R.sup.12分别代表氢原子或类似的低烷基团）或类似团代表的基团；R.sup.6代表由公式##STR2##（其中R.sup.19代表氢原子、低烷基团或类似物；R.sup.20、R.sup.21和R.sup.22分别代表氢原子、卤原子、羟基或类似物；r代表0或1到8的整数）的基团。
• COMPOUNDS USEFUL AS ANTIBIOTIC TOLERANCE INHIBITORS
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US20160052890A1

  公开（公告）日：2016-02-25

  The disclosure provides compounds and pharmaceutical compositions of the compounds useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds and salts of general Formula VIII Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a patient, including Pseudomonas aeruginosa infections, are also provided by the disclosure.

  本公开提供了化合物和药物组合物，这些化合物对治疗慢性和急性细菌感染有用。其中一些化合物是通式VIII的化合物和盐。本公开的某些化合物是MvfR抑制剂。MvfR抑制剂减少抗生素耐药细菌株的形成，对治疗革兰氏阴性细菌感染和减少铜绿假单胞菌的毒性有用。本公开还提供了治疗患者细菌感染的方法，包括铜绿假单胞菌感染。
• NITROGENOUS HETEROCYCLIC COMPOUND
  申请人：Eisai Co., Ltd.

  公开号：EP0607439A1

  公开（公告）日：1994-07-27

  A nitrogenous heterocyclic compound represented by general formula (I) or a pharmacologically acceptable salt thereof, efficacious in treating various ischemic cardiac diseases, wherein ring A represents a benzene, pyridine or cyclohexane ring; ring B represents a pyridine, pyrimidine or imidazole ring; R¹, R², R³ and R⁴ represent each hydrogen, halogen, lower alkoxy, etc.; R⁵ represents -NR¹¹R¹² (wherein R¹¹ and R¹² represent each hydrogen, lower alkyl, etc.), etc.; and R⁶ represents (a) (wherein R¹⁹ represents hydrogen, lower alkyl, etc.; R²⁰, R²¹ and R²² represent each hydrogen, halogen, hydroxy, etc.; and r represents an integer of 0.1 to 8), etc.

  一种由通式(I)代表的含氮杂环化合物或其药理学上可接受的盐，可有效治疗各种缺血性心脏病，其中环 A 代表苯环、吡啶环或环己烷环；环 B 代表吡啶环、嘧啶环或咪唑环；R¹、R²、R³ 和 R⁴ 分别代表氢、卤素、低级烷氧基等；R⁵ 代表 -NR¹R¹² (其中 R¹¹ 和 R¹² 分别代表氢、低级烷基等)；以及 R⁶ 代表 -NR¹R¹² (其中 R¹¹ 和 R¹² 分别代表氢、低级烷基等)。R⁵代表-NR¹R¹²（其中 R¹¹ 和 R¹² 分别代表氢、低级烷基等）等；以及 R⁶ 代表（a）（其中 R¹⁹ 代表氢、低级烷基等；R²⁰、R²¹ 和 R²² 分别代表氢、卤素、羟基等；以及 r 代表 0.1 至 8 的整数）等。