4-methoxy-6-methylbenzo[d][1,3]dioxole | 6443-70-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 4-methoxy-6-methylbenzo[d][1,3]dioxole
• 英文别名: 3,4-Methylendioxy-5-methoxy-toluol-(1)；4-methoxy-6-methyl-benzo[1,3]dioxole；4-Methoxy-6-methyl-1,3-benzodioxole
• CAS: 6443-70-5
• 化学式: C₉H₁₀O₃
• mdl: MFCD00666648
• 分子量: 166.177
• InChiKey: YFMBBFKIGQXWIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  肉豆蔻醛 在 二氯二茂钛 、 ammonia borane 、 lithium methanolate 作用下， 以 甲基叔丁基醚 为溶剂， 以54 %的产率得到4-methoxy-6-methylbenzo[d][1,3]dioxole
  参考文献：
  名称：

  钛催化的含氧化学品的穷举还原

  摘要：

  报道了一种涉及钛的催化体系，用于将羧酸衍生物彻底还原为相应的甲基化合物。该催化系统还适用于其他类型的含氧化学物质，如醇、醛、酮、内酯和羧酸盐，而这些产品可能在生物应用方面很有前景。初步机理研究表明，原位产生的 Ti III -H 物种是这种转变的关键。

  DOI：

  10.1002/anie.202209232

文献信息

• [EN] QUINOLONE COMPOUND<br/>[FR] COMPOSÉ QUINOLONE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2013029548A1

  公开（公告）日：2013-03-07

  The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile- associated diarrhea.

  本发明提供了一种化合物，其表示为式(I)，其中X为氢原子或氟原子；R为氢原子或烷基；R1为（1）环丙基，可选择地被1至3个卤原子取代，或（2）苯基，可选择地被1至3个卤原子取代；R2为烷基、烷氧基、卤代烷氧基、卤原子、氰基等；R3为7-氧代-7,8-二氢-1,8-萘啶基，3-吡啶基等，或其盐。本发明的化合物对厌氧菌艰难梭菌具有优异的抗菌活性，并可用于预防或治疗肠道感染，如厌氧菌艰难梭菌相关性腹泻。
• [EN] SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS SYK KINASE INHIBITORS<br/>[FR] NAPHTYRIDINES SUBSTITUÉES ET LEUR UTILISATION COMME INHIBITEURS DE SYK KINASE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2011092128A1

  公开（公告）日：2011-08-04

  The invention relates to new substituted naphthyridines of formula (1), as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among -O-R3 or -NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6 R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, -C1-6-alkylen-O-C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and Formula (I) is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, -C1-3-alkyl, -C1-3-haloalkyl, -O-C1-3-alkyl, -C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.

  该发明涉及公式（1）的新取代萘啉衍生物，以及其药理学上可接受的盐、对映体、非对映体异构体、立体异构体、水合物或溶剂化合物，其中R1从-O-R3或-NR3R4中选择，R3是C1-6-烷基，其被R5和R6取代，R5从氢、支链或直链C1-6-烷基、C2-6-烯基、-C1-6-烷基-氧-C1-3-烷基、C1-3-卤代烷基中选择，R6是环X，其中n为0或1，公式（I）为单键或双键，其中A、B、D和E分别独立地从CH2、CH、C、N、NH、O或S中选择，环X通过位置A、B、D或E连接到分子上，其中所述环X可以选择性地进一步被一个、两个或三个残基取代，每个残基分别从-氧化物、羟基、-C1-3-烷基、-C1-3-卤代烷基、-O-C1-3-烷基、-C1-3-醇基和卤素组成的群中选择，R4、R2、R7、R8、R9、R10、R11和Q的含义可以如权利要求1中所述，以及含有这些化合物的药物组合物。
• Hydrogenation of plant polyalkoxybenzene derivatives: convenient access to coenzyme Q0 analogues
  作者：Alexander E. Varakutin、Egor A. Muravsky、Ilia Yu. Shinkarev、Victor N. Khrustalev、Victor V. Semenov

  DOI：10.1016/j.mencom.2020.09.015

  日期：2020.9

  A technologically advanced protocol has been developed for converting plant allyl(polyalkoxy)benzenes to methyl- and propyl(polyalkoxy)benzenes being intermediates in the syntheses of coenzyme Q0 analogues. The key stage of allyl and benzaldehyde moieties hydrogenation was carried out in a periodical autoclave mode on highly porous ceramic block Pd-catalysts. These catalysts possess large surface area

  已经开发出技术上先进的方案，用于将植物烯丙基（聚烷氧基）苯转化为甲基和丙基（聚烷氧基）苯，它们是辅酶Q0类似物合成中的中间体。烯丙基和苯甲醛部分氢化的关键阶段是以周期性的高压釜模式在高度多孔的陶瓷嵌段Pd催化剂上进行的。这些催化剂具有大的表面积，低的水力阻力，显着的热稳定性和机械稳定性，多次循环和易于再生，可显着减少Pd的消耗。
• SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS MEDICAMENTS
  申请人：Hoffmann Matthias

  公开号：US20120028939A1

  公开（公告）日：2012-02-02

  The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R 1 is selected from among —O—R 3 or —NR 3 R 4 , R 3 is C 1-6 -alkyl which is substituted by R 5 and R 6 , R 5 is selected from hydrogen, branched or linear C 1-6 -alkyl, C 2-6 -alkenyl, —C 1-6 -alkylen-O—C 1-3 -alkyl, C 1-3 -haloalkyl, R 6 is ring X wherein n is either 0 or 1, and is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH 2 , CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, —C 1-3 -alkyl, —C 1-3 -haloalkyl, —O—C 1-3 -alkyl, —C 1-3 -alkanol and halogen, and wherein R 4 , R 2 , R 7 , R 8 , R 9 , R 10 , R 11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.

  该发明涉及公式1的新取代萘啉类化合物，以及其药理学上可接受的盐、对映体、旋光异构体、消旋体、水合物或溶剂合物，其中R1从—O—R3或—NR3R4中选择，R3是经R5和R6取代的C1-6烷基，R5从氢、支链或直链C1-6烷基、C2-6烯基、—C1-6烷基氧基-C1-3烷基、C1-3卤代烷基中选择，R6是环X，其中n为0或1，为单键或双键，A、B、D和E各自独立地从CH2、CH、C、N、NH、O或S中选择，环X通过位置A、B、D或E连接到分子，所述环X可以选择地进一步由氧代、羟基、—C1-3烷基、—C1-3卤代烷基、—O—C1-3烷基、—C1-3烷醇和卤素中的每个单独选择的一个、两个或三个残基取代，并且R4、R2、R7、R8、R9、R10、R11和Q可以具有如权利要求1中所给出的含义，以及含有这些化合物的药物组合物。
• [EN] PYRAZOLOPYRIDINE DERIVATIVES AND THEIR USE IN THERAPY<br/>[FR] DÉRIVÉS DE PYRAZOLOPYRIDINE ET LEUR UTILISATION EN THÉRAPIE
  申请人：HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT GMBH

  公开号：WO2016038045A1

  公开（公告）日：2016-03-17

  The present invention relates to pyrazolopyridine derivatives, which are useful as medicaments, pharmaceutical compositions comprising one or more of the pyrazolopyridine derivatives, and the use of one or more of the pyrazolopyridine derivatives in methods for treating and/or preventing a disease caused or mediated by a parasite of the family Trypanosomatidae.

  本发明涉及吡唑吡啶衍生物，其作为药物有用，包括一种或多种吡唑吡啶衍生物的制药组合物，以及使用一种或多种吡唑吡啶衍生物治疗和/或预防由Trypanosomatidae家族寄生虫引起或介导的疾病的方法。