3-((S)-2,5-Dioxo-oxazolidin-4-yl)-propionic acid butyl ester | 46724-52-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-((S)-2,5-Dioxo-oxazolidin-4-yl)-propionic acid butyl ester
• 英文别名: butyl 3-[(4S)-2,5-dioxo-1,3-oxazolidin-4-yl]propanoate
• CAS: 46724-52-1
• 化学式: C₁₀H₁₅NO₅
• 分子量: 229.233
• InChiKey: NWZQPSQDCFEQRT-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-((S)-2,5-Dioxo-oxazolidin-4-yl)-propionic acid butyl ester 、 正丁胺 以 乙腈 为溶剂， 反应 96.0h， 生成
  参考文献：
  名称：

  Julia, Sebastian; Masana, Jaume; Vega, Juan Carlos, Angewandte Chemie, 1980, vol. 92, # 11, p. 968 - 969

  摘要：

  DOI：
• 作为产物：
  描述：

  L-glutamic acid monobutyl ester 在 COCl₂ 作用下， 生成 3-((S)-2,5-Dioxo-oxazolidin-4-yl)-propionic acid butyl ester
  参考文献：
  名称：

  Julia, Sebastian; Masana, Jaume; Vega, Juan Carlos, Angewandte Chemie, 1980, vol. 92, # 11, p. 968 - 969

  摘要：

  DOI：

文献信息

• An Unconventional Method for Purifying the N-carboxyanhydride Derivatives of γ-alkyl-L-glutamates
  作者：Drew S. Poché、Michael J. Moore、Jennifer L. Bowles

  DOI：10.1080/00397919908086042

  日期：1999.3

  Abstract Common impurities in the phosgenation of α -amino acids to produce their N-carboxyanhydride (NCA) derivatives include hydrogen chloride and the hydrochloride salt of the starting amino acid. These impurities can be effectively removed by washing the reaction mixture with water and aqueous bicarbonate at 0 °C prior to isolation of the NCA., despite the well known sensitivity of the NCA to water

  摘要 α-氨基酸光气化以生产其 N-羧酸酐 (NCA) 衍生物时常见的杂质包括氯化氢和起始氨基酸的盐酸盐。这些杂质可以通过在分离 NCA 之前在 0 °C 下用水和碳酸氢盐水溶液洗涤反应混合物来有效去除。尽管众所周知 NCA 对水敏感。该方法应该特别适用于分离的 NCA 衍生物因为通过重结晶或溶剂洗涤来纯化它们是不可行的。该研究特别涉及从各种 γ-烷基-L-谷氨酸盐和 γ-苄基-L-谷氨酸盐中纯化 NCA 衍生物。
• STABLE HELICAL IONIC POLYPEPTIDES
  申请人：Cheng Jianjun

  公开号：US20130274173A1

  公开（公告）日：2013-10-17

  The invention provides polymers comprising Formula I: wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally substituted carbon chain that is optionally interrupted by moieties such as oxygen, nitrogen, sulfur, phosphorus, or silicon. Charge is a moiety having a positive or negative charge on a heteroatom, such as nitrogen, oxygen, phosphorus, or sulfur; where the Linker separates the monomer and the Charge by at least six linear atoms. The invention also provides methods of preparing the polymers and the copolymers and methods of using the polymers and copolymers, for example, as drug delivery systems, as membrane penetrating peptides, and as therapeutic agents.

  本发明提供了具有以下式子（I）的聚合物：其中单体是由2、3、4、5、6或7个碳原子组成的重复单元，且单体通过酰胺或酯键连接在一起；n约为6到约1000；连接体是一种可以选择性地被氧、氮、硫、磷或硅等官能团中断的可选择性取代的碳链。电荷是具有异原子上的正或负电荷的官能团，例如氮、氧、磷或硫；其中连接体至少由六个线性原子将单体和电荷分开。本发明还提供了制备聚合物和共聚物的方法，以及使用聚合物和共聚物的方法，例如作为药物传递系统、作为膜穿透肽和作为治疗剂。
• US9243040B2
  申请人：——

  公开号：US9243040B2

  公开（公告）日：2016-01-26
• [EN] STABLE HELICAL IONIC POLYPEPTIDES<br/>[FR] POLYPEPTIDES IONIQUES HÉLICOÏDAUX STABLES
  申请人：UNIV ILLINOIS

  公开号：WO2012075147A2

  公开（公告）日：2012-06-07

  The invention provides polymers comprising Formula 1 wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally substituted carbon chain that is optionally interrupted by moieties such as oxygen, nitrogen, sulfur, phosphorus, or silicon. Charge is a moiety having a positive or negative charge on a heteroatom, such as nitrogen, oxygen, phosphorus, or sulfur; where the Linker separates the monomer and the Charge by at least six linear atoms. The invention also provides methods of preparing the polymers and the copolymers and methods of using the polymers and copolymers, for example, as drug delivery systems, as membrane penetrating peptides, and as therapeutic agents.
• Julia, Sebastian; Masana, Jaume; Vega, Juan Carlos, Angewandte Chemie, 1980, vol. 92, # 11, p. 968 - 969
  作者：Julia, Sebastian、Masana, Jaume、Vega, Juan Carlos

  DOI：——

  日期：——