γ-[2-(2-methoxyethoxy)ethyl]-L-glutamate N-carboxyanhydride | 1136297-22-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γ-[2-(2-methoxyethoxy)ethyl]-L-glutamate N-carboxyanhydride
• 英文别名: 2-(2-methoxyethoxy)ethyl 3-[(4S)-2,5-dioxo-1,3-oxazolidin-4-yl]propanoate
• CAS: 1136297-22-7
• 化学式: C₁₁H₁₇NO₇
• 分子量: 275.258
• InChiKey: NJWNNEXBUWNPCR-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  二乙二醇单甲醚 、 L-谷氨酸 在 硫酸 作用下， 以 四氢呋喃 为溶剂， 生成 γ-[2-(2-methoxyethoxy)ethyl]-L-glutamate N-carboxyanhydride
  参考文献：
  名称：

  Thermoresponsive Polypeptides from Pegylated Poly-l-glutamates

  摘要：

  The synthesis and characterization of new thermoresponsive pegylated poly-L-glutamate (poly-L-EG(x)Glu) are described. The obtained polypeptides display low critical solution temperature (LCST) behaviors in water, and the LCST can be tuned via copolymerization of different amino acid monomers at varied molar ratio. This is the first example of thermoresponsive polypeptide made from ring-opening polymerization of alpha-amino acid N-carboxyanhydrides (NCAs). Circular dichroism characterizations reveal that the secondary structure of poly-L-EG(x)Glu depended on the chain length of the side chain.

  DOI：

  10.1021/bm200849m

文献信息

• Thermoresponsive Polypeptides from Pegylated Poly-<scp>l</scp>-glutamates
  作者：Chongyi Chen、Zhaohui Wang、Zhibo Li

  DOI：10.1021/bm200849m

  日期：2011.8.8

  The synthesis and characterization of new thermoresponsive pegylated poly-L-glutamate (poly-L-EG(x)Glu) are described. The obtained polypeptides display low critical solution temperature (LCST) behaviors in water, and the LCST can be tuned via copolymerization of different amino acid monomers at varied molar ratio. This is the first example of thermoresponsive polypeptide made from ring-opening polymerization of alpha-amino acid N-carboxyanhydrides (NCAs). Circular dichroism characterizations reveal that the secondary structure of poly-L-EG(x)Glu depended on the chain length of the side chain.