hydron;methyl (8S)-8-(bromomethyl)-2-methyl-4-(4-methylpiperazine-1-carbonyl)oxy-6-(5,6,7-trimethoxy-3a,7a-dihydro-1H-indole-2-carbonyl)-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1-carboxylate;bromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: hydron;methyl (8S)-8-(bromomethyl)-2-methyl-4-(4-methylpiperazine-1-carbonyl)oxy-6-(5,6,7-trimethoxy-3a,7a-dihydro-1H-indole-2-carbonyl)-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1-carboxylate;bromide
• 化学式: C32H39Br2N5O8
• 分子量: 781.5
• InChiKey: JALRQNYTBWZXKJ-RZDYCKLASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.93
• 重原子数：
  47
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• CD44 binding peptides
  申请人：Endosignals Medizintechnik GmbH

  公开号：EP2886126A1

  公开（公告）日：2015-06-24

  The present invention relates to a protein which binds to the domain encoded by exon 9 of human CD44 (CD44ex9), to fusion proteins and conjugates of said protein and especially to nanoparticles conjugated to said protein. The invention further relates to a method of production for the protein and the respective conjugated nanoparticles and the use of the protein of the invention for treatment and diagnosis of cancer diseases.

  本发明涉及一种与人 CD44 外显子 9（CD44ex9）编码结构域结合的蛋白质、所述蛋白质的融合蛋白和共轭物，特别是与所述蛋白质共轭的纳米颗粒。本发明还涉及该蛋白质和相应共轭纳米颗粒的生产方法，以及本发明蛋白质在癌症疾病治疗和诊断中的应用。
• Nanoparticle conjugated to CD44 binding peptides
  申请人：Exchange Imaging Technologies GmbH

  公开号：EP2886126B1

  公开（公告）日：2017-06-07
• CD44 BINDING PEPTIDES
  申请人：Exchange Imaging Technologies GmbH

  公开号：EP3086802A1

  公开（公告）日：2016-11-02
• SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL
  申请人：Brennan Anthony B.

  公开号：US20100226943A1

  公开（公告）日：2010-09-09

  Disclosed herein is an article that includes a first plurality of spaced features. The spaced features are arranged in a plurality of groupings; the groupings of features include repeat units; the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway. The plurality of spaced features provide the article with an engineered roughness index of about 5 to about 20.
• US9016221B2
  申请人：——

  公开号：US9016221B2

  公开（公告）日：2015-04-28