2-(3-Methoxyphenyl)morpholin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-(3-Methoxyphenyl)morpholin-3-one
• 英文别名: 2-(3-methoxyphenyl)morpholin-3-one
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.23
• InChiKey: TYHJHRVEEKCVLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-Methoxyphenyl)morpholin-3-one 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 2-(3-hydroxyphenyl)morpholin-3-one
  参考文献：
  名称：

  2-PHENYLMORPHOLINE AND 2-PHENYL(THIO)MORPHOLINE COMPOUNDS AND USES THEREOF

  摘要：

  Provided herein is a compound of Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X, Y, R1, R2, R3, R4, m, n, o) are as disclosed herein. Also provided herein are pharmaceutical compositions comprising a compound of Structural Formula I, or a pharmaceutically acceptable salt thereof, and methods of using the compounds, pharmaceutically acceptable salts thereof and pharmaceutical compositions of the foregoing,e.g., to treat a neurological or psychiatric disease or disorder, or a metabolic disease, disorder or condition.

  公开号：

  WO2024118488A1
• 作为产物：
  描述：

  3-甲氧基苯乙酸甲酯 在 N-溴代丁二酰亚胺(NBS) 、 silver trifluoromethanesulfonate 、 三氟乙酸 、 过氧化苯甲酰 作用下， 以 四氯化碳 、 二氯甲烷 为溶剂， 反应 8.0h， 生成 2-(3-Methoxyphenyl)morpholin-3-one
  参考文献：
  名称：

  2-PHENYLMORPHOLINE AND 2-PHENYL(THIO)MORPHOLINE COMPOUNDS AND USES THEREOF

  摘要：

  Provided herein is a compound of Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X, Y, R1, R2, R3, R4, m, n, o) are as disclosed herein. Also provided herein are pharmaceutical compositions comprising a compound of Structural Formula I, or a pharmaceutically acceptable salt thereof, and methods of using the compounds, pharmaceutically acceptable salts thereof and pharmaceutical compositions of the foregoing,e.g., to treat a neurological or psychiatric disease or disorder, or a metabolic disease, disorder or condition.

  公开号：

  WO2024118488A1

文献信息

• 2-PHENYLMORPHOLINE AND 2-PHENYL(THIO)MORPHOLINE COMPOUNDS AND USES THEREOF
  申请人：[en]SUMITOMO PHARMA AMERICA, INC.

  公开号：WO2024118488A1

  公开（公告）日：2024-06-06

  Provided herein is a compound of Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X, Y, R1, R2, R3, R4, m, n, o) are as disclosed herein. Also provided herein are pharmaceutical compositions comprising a compound of Structural Formula I, or a pharmaceutically acceptable salt thereof, and methods of using the compounds, pharmaceutically acceptable salts thereof and pharmaceutical compositions of the foregoing,e.g., to treat a neurological or psychiatric disease or disorder, or a metabolic disease, disorder or condition.